{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T08:06:19Z","timestamp":1793520379943,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T00:00:00Z","timestamp":1618704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA212147"],"award-info":[{"award-number":["R01CA212147"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>The Food and Drug Administration has cleared a probe\u2010based near\u2010infrared autofluorescence (NIRAF) detection system called PTeye\u2122 as an adjunct tool for label\u2010free intraoperative parathyroid gland (PG) identification. Since PTeye\u2122 has been investigated only in a \u201cblinded\u201d manner to date, this study describes the preliminary impressions of PTeye\u2122 when used by surgeons without being blinded to the device output.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients undergoing thyroid and parathyroid procedures were prospectively recruited. Target tissues were intraoperatively assessed with PTeye\u2122. The surgeon's confidence in PG identification was recorded concomitantly with NIRAF parameters that were output in real\u2010time from PTeye\u2122.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A retrospective review of prospectively collected data on 83 patients was performed. PTeye\u2122 was used for interrogating 336 target tissues in 46 parathyroid and 37 thyroid procedures. PTeye\u2122 yielded an overall accuracy of 94.3% with a positive predictive value of 93.0% and a negative predictive value of 100%. An increase in confidence for intraoperative PG identification with PTeye\u2122 was observed by all three participating high\u2010volume surgeons, irrespective of their level of accrued surgical experience.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Probe\u2010based NIRAF detection with PTeye\u2122 can be a valuable adjunct device to intraoperatively identify PGs for surgeons of varied training and experience.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26500","type":"journal-article","created":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T19:59:17Z","timestamp":1618775957000},"page":"271-281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Initial clinical experiences using the intraoperative probe\u2010based parathyroid autofluorescence identification system\u2014PTeye\u2122 during thyroid and parathyroid procedures"],"prefix":"10.1002","volume":"124","author":[{"given":"Colleen M.","family":"Kiernan","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology and Endocrine Surgery, Department of Surgery Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5910-8804","authenticated-orcid":false,"given":"Giju","family":"Thomas","sequence":"additional","affiliation":[{"name":"Vanderbilt Biophotonics Center Vanderbilt University  Nashville Tennessee USA"},{"name":"Department of Biomedical Engineering Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naira","family":"Baregamian","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology and Endocrine Surgery, Department of Surgery Vanderbilt University Medical Center  Nashville Tennessee 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