{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:52:23Z","timestamp":1791820343243,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Clinicopathologic characteristics have prognostic value in clinical stage IB\u2010II patients with melanoma. Little is known about the prognostic value of obesity that has been associated with an increased risk for several cancer types and worsened prognosis after diagnosis. This study aims to examine effects of obesity on outcome in patients with clinical stage IB\u2010II melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospectively recorded data of patients with clinical stage IB\u2010II melanoma who underwent sentinel lymph node biopsy (SLNB) between 1995 and 2018 at the University Medical Center of Groningen were collected from medical files and retrospectively analyzed. Cox\u2010regression analyses were used to determine associations between obesity (body mass index&gt;\u200930), tumor (location, histology, Breslow\u2010thickness, ulceration, mitotic rate, SLN\u2010status) and patient\u2010related variables (gender, age, and social\u2010economic\u2010status [SES]) and disease\u2010free interval (DFI), melanoma\u2010specific survival (MSS), and overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 715 patients, 355 (49.7%) were women, median age was 55 (range 18.6\u201089) years, 149 (20.8%) were obese. Obesity did not significantly affect DFI (adjusted hazard ratio [HR]\u2009=\u20091.40; 95% confidence interval [CI]\u2009=\u20090.98\u20132.00; <jats:italic>p<\/jats:italic>\u2009=\u20090.06), MSS (adjusted HR\u2009=\u20091.48;95%CI\u2009=\u20090.97\u20132.25; <jats:italic>p<\/jats:italic>\u2009=\u20090.07), and OS (adjusted HR\u2009=\u20091.25; 95% CI\u2009=\u20090.85\u20131.85; <jats:italic>p<\/jats:italic>\u2009=\u20090.25). Increased age, arm location, increased Breslow\u2010thickness, ulceration, increased mitotic rate, and positive SLN\u2010status were significantly associated with decreased DFI, MSS, and OS. Histology, sex, and SES were not associated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Obesity was not associated with DFI, MSS, or OS in patients with clinical stage IB\u2010II melanoma who underwent SLNB.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26555","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T13:57:22Z","timestamp":1622815042000},"page":"655-664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Obesity is not associated with disease\u2010free interval, melanoma\u2010specific survival, or overall survival in patients with clinical stage IB\u2010II melanoma after SLNB"],"prefix":"10.1002","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-207X","authenticated-orcid":false,"given":"Eric A.","family":"Deckers","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schelto","family":"Kruijff","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Bastiaannet","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"van Ginkel","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josette E. 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