{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:42:23Z","timestamp":1762508543012},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Patients with locally advanced pancreatic cancer (LAPC) are increasingly treated with FOLFIRINOX, resulting in improved survival and resection of tumors that were initially unresectable. It remains unclear, however, which specific patients benefit from FOLFIRINOX. Two nomograms were developed predicting overall survival (OS) and resection at the start of FOLFIRINOX for LAPC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From our multicenter, prospective LAPC registry in 14 Dutch hospitals, LAPC patients starting first\u2010line FOLFIRINOX (April 2015\u2013December 2017) were included. Stepwise backward selection according to the Akaike Information Criterion was used to identify independent baseline predictors for OS and resection. Two prognostic nomograms were generated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 252 patients were included, with a median OS of 14 months. Thirty\u2010two patients (13%) underwent resection, with a median OS of 23 months. Older age, female sex, Charlson Comorbidity Index \u22641, and CA 19.9\u2009&lt;\u2009274 were independent factors predicting a better OS (c\u2010index: 0.61). WHO ps &gt;1, involvement of the\u00a0superior mesenteric artery, celiac trunk, and superior mesenteric vein\u2009\u2265\u2009270\u00b0 were independent factors decreasing the probability of resection (c\u2010index: 0.79).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Two nomograms were developed to predict OS and resection in patients with LAPC before starting treatment with FOLFIRINOX. These nomograms could be beneficial in the shared decision\u2010making process and counseling of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26567","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T16:01:54Z","timestamp":1623427314000},"page":"589-597","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Predicting overall survival and resection in patients with locally advanced pancreatic cancer treated with FOLFIRINOX: Development and internal validation of two nomograms"],"prefix":"10.1002","volume":"124","author":[{"given":"Lilly J. H.","family":"Brada","sequence":"first","affiliation":[{"name":"Department of Surgery, UMC Utrecht Cancer Center St Antonius Hospital Nieuwegein and Meander Medical Center  Utrecht The Netherlands"},{"name":"Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marieke S.","family":"Walma","sequence":"additional","affiliation":[{"name":"Department of Surgery, UMC Utrecht Cancer Center St Antonius Hospital Nieuwegein and Meander Medical Center  Utrecht The Netherlands"},{"name":"Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lois A.","family":"Daamen","sequence":"additional","affiliation":[{"name":"Department of Surgery, UMC Utrecht Cancer Center St Antonius Hospital Nieuwegein and Meander Medical Center  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stijn","family":"van Roessel","sequence":"additional","affiliation":[{"name":"Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald M.","family":"van Dam","sequence":"additional","affiliation":[{"name":"Department of Surgery Maastricht UMC+  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignace H.","family":"de Hingh","sequence":"additional","affiliation":[{"name":"Department of Surgery Catharina Hospital  Eindhoven The Netherlands"},{"name":"Department of Epidemiology Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike L. 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