{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:33:29Z","timestamp":1771630409762,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We conducted a prospective study to determine the diagnostic performance of positron emission tomography\u2013computed tomography (PET\u2010CT) for lymph node metastasis in colorectal cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled patients scheduled to receive curative surgery with lymph node dissection for colorectal adenocarcinoma who underwent contrast\u2010enhanced abdominopelvic CT and PET\u2010CT before surgery and who had primary lesions of cT2 or deeper. A radiologist determined the fluorodeoxyglucose uptake and the standardized uptake value (SUV) and metabolic volume (MV) to diagnose metastasis in cases with enlarged lymph nodes (\u22657\u2009mm long in minor diameter) on contrast\u2010enhanced CT. Two gastrointestinal surgeons intraoperatively identified target lymph nodes to assess the association between images and pathological findings. The diagnostic performance (i.e., sensitivity, specificity, and positive and negative predictive values) for lymph node metastasis was determined using multilevel logistic modeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 205 colorectal cancer patients were enrolled from February 2018 to April 2020 and 194 patients were analyzed in this study. The sensitivity, specificity, and positive and negative predictive values of PET\u2010CT were 15.3% (13.4%\u201317.5%), 100.0% (99.0%\u2013100.0%), 100.0% (51.2%\u2013100.0%), and 98.7% (98.5%\u201399.0%), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PET\u2010CT is a useful modality for determining the presence of metastasis in swollen lymph nodes on contrast\u2010enhanced CT in colorectal cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26602","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T06:21:26Z","timestamp":1626330086000},"page":"1085-1090","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The additional diagnostic impact of positron emission tomography\u2013computed tomography for lymph node metastasis from colorectal cancer: A prospective lymph node level analysis"],"prefix":"10.1002","volume":"124","author":[{"given":"Yukitoshi","family":"Todate","sequence":"first","affiliation":[{"name":"Department of Surgery, Southern TOHOKU Research Institute for Neuroscience Southern TOHOKU General Hospital  Koriyama Japan"},{"name":"Department of Minimally Invasive Surgical and Medical Oncology Fukushima Medical University  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3492-9881","authenticated-orcid":false,"given":"Michitaka","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Surgery, Southern TOHOKU Research Institute for Neuroscience Southern TOHOKU General Hospital  Koriyama Japan"},{"name":"Department of Minimally Invasive Surgical and Medical Oncology Fukushima Medical University  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Healthcare Epidemiology Kyoto University School of Public Health  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Saginoya","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Southern TOHOKU Research Institute for Neuroscience Southern TOHOKU General Hospital  Koriyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Minimally Invasive Surgical and Medical Oncology Fukushima Medical University  Fukushima Japan"},{"name":"Department of Radiology Southern TOHOKU Proton Beam Therapy Center  Koriyama Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Southern TOHOKU General Hospital  Koriyama Fukushima 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