{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:27:30Z","timestamp":1747150050764,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Talimogene laherparepvec (T\u2010VEC) is a genetically modified herpes simplex virus\u20101\u2010based oncolytic immunotherapy and has been approved for the local treatment of unresectable (stage IIIB\/C and IVM1a) cutaneous melanoma. During T\u2010VEC treatment, tumor response is often evaluated using [18F]2\u2010fluoro\u20102\u2010deoxy\u2010\n<jats:sc>d<\/jats:sc>\u2010glucose(FDG) positron emission tomography\/computed tomography (PET\/CT). In a Dutch cohort (<jats:italic>n<\/jats:italic>\u2009=\u2009173), almost one\u2010third of patients developed new\u2010onset FDG uptake in uninjected locoregional lymph nodes during T\u2010VEC. In 36 out of 53 (68%) patients with new nodal FDG uptake, nuclear medicine physicians classified this FDG uptake as \u201csuspected metastases\u201d without clinical or pathological confirmation in the majority of patients. These false positive results indicate that new\u2010onset FDG uptake in locoregional lymph nodes during T\u2010VEC treatment does not necessarily reflect progressive disease, but may be associated with immune infiltration. In current clinical practice, physicians should be aware of the high false positive rate of FDG uptake during treatment with T\u2010VEC in patients with melanoma. Therefore, pathological examination of lymph node lesions with new FDG uptake is recommended to differentiate between progressive disease and immune infiltration after treatment with T\u2010VEC.<\/jats:p>","DOI":"10.1002\/jso.26607","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T08:41:15Z","timestamp":1625733675000},"page":"1161-1165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["False positive FDG uptake in melanoma patients treated with talimogene laherparepvec (T\u2010VEC)"],"prefix":"10.1002","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9045-2171","authenticated-orcid":false,"given":"Evalyn E. A. 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