{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:44:03Z","timestamp":1773269043248,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the safety, feasibility and clinical effect of transvaginal natural orifice specimen extraction surgery (NOSES) in 3D laparoscopic nephroureterectomy (LNU) for upper tract urothelial carcinoma (UTUC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was made of 16 female patients who underwent 3D LNU and NOSES in the Department of Urology, Cancer Hospital, Chinese Academy of Medical Sciences from June 2019 to December 2020. The basic clinical data, perioperative related data, perioperative complications, visual analogue pain score (VAS), postoperative scar assessment questionnaire (PSAQ) at 3 months, female pelvic floor dysfunction questionnaire (PFDI\u201020) and female sexual function index questionnaire (FSFI) at preoperative and postoperative 3 months were analyzed and evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The surgery was successfully completed in all 16 patients, and none of them was converted to open surgery. No postoperative complications, such as abdominal incision\u2010related infection. No cases of local recurrence and distant metastasis were observed during follow\u2010up of 3 to 21 months. The VAS scores at 24\u2009h and 48\u2009h after operation were 2.9\u2009\u00b1\u20090.7, 1.3\u2009\u00b1\u20090.6, respectively. PSAQ scores at 3 months after operation were 34.3\u2009\u00b1\u20093.3. PFDI\u201020 scores of women preoperative and postoperative 3 months were 6.25\u2009\u00b1\u20091.75, 6.3\u2009\u00b1\u20091.8, respectively, and the difference was not statistically significant (<jats:italic>p<\/jats:italic>\u2009=\u20090.924). There was no significant difference in FSFI scores between preoperative and postoperative 3 months (<jats:italic>p<\/jats:italic>\u2009=\u20090.892).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transvaginal NOSES in 3D LNU for UTUC is safe, feasible and practical. The successful development of this technique has laid a solid foundation for further clinical application and promotion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26608","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T12:57:31Z","timestamp":1626440251000},"page":"1200-1206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A new and practical surgical technique of transvaginal natural orifice specimen extraction surgery (NOSES) in laparoscopic nephroureterectomy\u2014an initial clinical experience"],"prefix":"10.1002","volume":"124","author":[{"given":"Qinxin","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Urology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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