{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:16:00Z","timestamp":1765610160849,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The prognostic significance of regression in predicting melanoma recurrences is unknown. We present a large multicenter study correlating regression with recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Sentinel Lymph Node Working Group database was queried from 1993 to 2018 for cases with regression data. Clinicopathologic factors were correlated with overall and first\u2010site of recurrence and with recurrence\u2010free survival (RFS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 4790 patients and the median follow\u2010up was 39.6 months. Regression and recurrences were seen in 1081 (22.6%) and 773 (16.1%) cases, respectively. First\u2010site locoregional and distant recurrences were seen in 412 (8.6%) and 352 (7.3%) patients, respectively. Regression was seen in 15.8% and 24.7% of all cases with and without recurrences (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), respectively, while regression was seen in 14.3% and 17.9% of first\u2010site locoregional and distant recurrent cases, respectively, compared with 23.3% and 22.9% of patients with regression and without first\u2010site locoregional and distant recurrences, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.29). On multivariable analysis, after controlling for age, gender, thickness, ulceration, lymphovascular invasion, and sentinel lymph node status, regression significantly predicted improved RFS (<jats:italic>p<\/jats:italic>\u2009=\u20090.004) and fewer first\u2010site regional recurrences (<jats:italic>p<\/jats:italic>\u2009=\u20090.017).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data suggest that regression is a favorable prognostic marker in melanoma and predicts significantly better RFS and decreased first\u2010site regional recurrences.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26678","type":"journal-article","created":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T06:39:28Z","timestamp":1631947168000},"page":"229-238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Regression in melanoma is significantly associated with a lower regional recurrence rate and better recurrence\u2010free survival"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2242-0386","authenticated-orcid":false,"given":"Sarayu","family":"Subramanian","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology Oregon Health &amp; Science University Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Texas A&amp;M University College Station Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Texas A&amp;M University College Station Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley P.","family":"Leong","sequence":"additional","affiliation":[{"name":"Division of Cutaneous Oncology, Center for Melanoma Research and Treatment California Pacific Medical Center and Research Institute San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Kashani\u2010Sabet","sequence":"additional","affiliation":[{"name":"Division of Cutaneous Oncology, Center for Melanoma Research and Treatment California Pacific Medical Center and Research Institute San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6559-8312","authenticated-orcid":false,"given":"Richard L.","family":"White","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, Levine Cancer Institute Atrium Health Carolinas Medical Center Charlotte North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6886-4468","authenticated-orcid":false,"given":"Jonathan S.","family":"Zager","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology Moffitt Cancer Center Tampa Florida USA"},{"name":"Department of Oncologic Sciences, Morsani School of Medicine University of South Florida Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vernon K.","family":"Sondak","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology Moffitt Cancer Center Tampa Florida USA"},{"name":"Department of Oncologic Sciences, Morsani School of Medicine University of South Florida Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane L.","family":"Messina","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology Moffitt Cancer Center Tampa Florida USA"},{"name":"Department of Oncologic Sciences, Morsani School of Medicine University of South Florida Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Pockaj","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology and Endocrine Surgery Mayo Clinic Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi E.","family":"Kosiorek","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology and Endocrine Surgery Mayo Clinic Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Vetto","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Oregon Health &amp; Science University Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham","family":"Fowler","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Oregon Health &amp; Science University Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Schlomo","family":"Schneebaum","sequence":"additional","affiliation":[{"name":"Department of Surgery Tel\u2010Aviv Sourasky Medical Center Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0741-2089","authenticated-orcid":false,"given":"Dale","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Oregon Health &amp; Science University Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07369-w"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000211"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9098(199804)67:4<228::AID-JSO4>3.0.CO;2-A"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199201000-00009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/647684"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1990.tb00757.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9675-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.5032"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12586"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2021.05.010"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.2340"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.922"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481107700819"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.06.054"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.43"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197811)42:5<2282::AID-CNCR2820420528>3.0.CO;2-V"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2017.8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2019.0018"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1992.01420040034005"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15552"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.397"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200506000-00005"},{"key":"e_1_2_8_24_1","first-page":"99","article-title":"Regressing thin cutaneous malignant melanomas (< or = 1.0 mm) are associated with angiogenesis","volume":"143","author":"Barnhill RL","year":"1993","journal-title":"Am J Pathol"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/81.24.1893"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70020-4"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.5.603"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1987.01660340088026"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14280"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30407"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2013.1335"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v7.i2.174"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2011.05.003"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310460"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01902"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198808000-00004"},{"key":"e_1_2_8_37_1","first-page":"1","article-title":"Histological regression in melanoma: impact on sentinel lymph node status and survival","volume":"10","author":"Aivazian K","year":"2021","journal-title":"Mod Pathol"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.26678","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jso.26678","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.26678","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T03:04:15Z","timestamp":1693191855000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.26678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,17]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1002\/jso.26678"],"URL":"https:\/\/doi.org\/10.1002\/jso.26678","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"type":"print","value":"0022-4790"},{"type":"electronic","value":"1096-9098"}],"subject":[],"published":{"date-parts":[[2021,9,17]]},"assertion":[{"value":"2021-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}