{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:27:33Z","timestamp":1740104853170,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["T32 CA090217"],"award-info":[{"award-number":["T32 CA090217"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Thoracic epidurals are commonly recommended in enhanced recovery protocols, though they may cause hypotension and urinary retention. Peripheral nerve blocks using liposomal bupivacaine are a potential alternative, though they have not been extensively studied in major cancer operations with an epigastric incision.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective review of prospectively collected data following the transition from thoracic epidural to liposomal peripheral nerve blocks in patients undergoing major oncologic surgery. Patients receiving peripheral nerve blocks were compared to those receiving thoracic epidural. Outcome variables included postoperative opioid use (milligram morphine equivalents [MME]), severe pain, and postoperative complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010seven of 102 patients studied (46%) received peripheral nerve blocks. Opioid use was higher in the peripheral nerve block group during the 0\u201324\u2009h (116 vs. 94\u2009MME, <jats:italic>p<\/jats:italic>\u2009=\u20090.04) and 24\u201348\u2009h postoperative period (94 vs. 23\u2009MME, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). There was no significant difference in severe pain, hypotension, urinary retention, or ileus. Peripheral nerve blocks were associated with earlier ambulation (1 vs. 2 days, <jats:italic>p<\/jats:italic>\u2009=\u20090.04), though other milestones were similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Liposomal peripheral nerve blocks were associated with increased opioid use compared to thoracic epidural. On the basis of our results, thoracic epidural might be preferred in surgical oncology patients with an epigastric incision.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26711","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T22:01:11Z","timestamp":1633730471000},"page":"387-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Peripheral nerve blocks with liposomal bupivacaine are associated with increased opioid use compared to thoracic epidural in patients with an epigastric incision"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1139-9822","authenticated-orcid":false,"given":"Taylor J.","family":"Aiken","sequence":"first","affiliation":[{"name":"Department of Surgery University of Wisconsin Hospitals and Clinics Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Padilla","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health University of Wisconsin Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Lemaster","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Wisconsin Hospitals and Clinics Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Ronnekleiv\u2010Kelly","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Wisconsin Hospitals and Clinics Madison Wisconsin USA"},{"name":"Division of Surgical Oncology University of Wisconsin Hospitals and Clinics Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Wisconsin Hospitals and Clinics Madison Wisconsin USA"},{"name":"Division of Surgical Oncology University of Wisconsin Hospitals and Clinics Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca M.","family":"Minter","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Wisconsin Hospitals and Clinics Madison Wisconsin USA"},{"name":"Division of Surgical Oncology University of Wisconsin Hospitals and Clinics Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Ethier","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Wisconsin Hospitals and Clinics Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5539-0734","authenticated-orcid":false,"given":"Daniel E.","family":"Abbott","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Wisconsin Hospitals and Clinics Madison Wisconsin USA"},{"name":"Division of Surgical Oncology University of Wisconsin Hospitals and Clinics Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2005.02.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.08.011"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199408000-00015"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.02.074"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000747"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200407000-00021"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2017.0337"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2018.04.021"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001211"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2011.06700.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.06.008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-015-0338-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2016.04.012"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e318169d03b"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.08.046"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf053"}],"container-title":["Journal 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