{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:36:22Z","timestamp":1785897382429,"version":"3.56.0"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Breast\u2010conserving surgery (BCS) is followed by reoperations in approximately 25%. Reoperations lead to an increased risk of infection and wound healing problems as well as a worse cosmetic outcome. Several technical approaches for an intraoperative margin assessment to decrease the reoperation rate are under evaluation, some of them are still experimental.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective single\u2010arm\u00a0post\u2010marketing study with 60 patients undergoing BCS for ductal carcinoma in situ (DCIS) and invasive breast cancer was conducted. The specimen was intraoperatively examined by the ClearSight\u2122 system, a mobile magnetic resonance imaging system that is based on a diffusion\u2010weighted imaging protocol. However, the results were blinded to the surgeon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ClearSight\u2122 system was performed for both ductal and lobular breast cancer and DCIS, with a sensitivity of 0.80 (95% confidence interval [CI]: 0.44\u20130.96) and a specificity of 0.84 (95% CI 0.72\u20130.92), with an overall diagnostic accuracy of 80%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Had the ClearSight\u2122 been known to the surgeon intraoperatively, the reoperation rate would have been reduced by 83% for invasive carcinoma, from 10% to 2%, and 50% for DCIS, from 30% to 15% reoperations. A trial designed to examine the impact on reoperation rates is currently ongoing.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26721","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T16:45:43Z","timestamp":1635785143000},"page":"361-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Magnetic resonance imaging system for intraoperative margin assessment for DCIS and invasive breast cancer using the ClearSight\u2122 system in breast\u2010conserving surgery\u2014Results from a postmarketing study"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8800-8044","authenticated-orcid":false,"given":"Marc","family":"Thill","sequence":"first","affiliation":[{"name":"Department of Gynecology and Gynecological Oncology Agaplesion Markus Krankenhaus Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Szwarcfiter","sequence":"additional","affiliation":[{"name":"Clear\u2010Cut Medical Ltd. Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Kelling","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Gynecological Oncology Agaplesion Markus Krankenhaus Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"van Haasteren","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Gynecological Oncology Agaplesion Markus Krankenhaus Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Kolka","sequence":"additional","affiliation":[{"name":"Clear\u2010Cut Medical Ltd. Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefa","family":"Noelke","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Gynecological Oncology Agaplesion Markus Krankenhaus Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachi","family":"Peles","sequence":"additional","affiliation":[{"name":"Clear\u2010Cut Medical Ltd. Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Papa","sequence":"additional","affiliation":[{"name":"General Surgery Unit Assuta Medical Center Tel\u2010Aviv Israel"},{"name":"Sackler School of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Aulmann","sequence":"additional","affiliation":[{"name":"OptiPath Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanir","family":"Allweis","sequence":"additional","affiliation":[{"name":"Medical Director, Breast Health Center Kaplan Medical Cente Rehovot Israel"},{"name":"Faculty of Medicine Hebrew University Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Cancer IAfRo. World Cancer Report.2014"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.8.1668"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20153"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/35021093"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2012.01.004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2008.03.007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)80033-6"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200202000-00013"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(97)89558-X"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2006.02.026"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605513"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-4-26"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1075-122X.2005.21617.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e3181b9cf31"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200110000-00005"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860600681569"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.43"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00112-1"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9777-x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2007.10.001"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343660"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0609-z"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.18.5.9747612"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.164.1.7998574"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(00)00500-6"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001897"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.03.085"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2003.10.008"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61232-X"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-010-0602-4"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10140"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3481-4"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2009.01.008"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00292-019-0578-3"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0646-4630"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23634"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24246"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2008.06.024"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3602-0"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2007.06.013"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2013.11.002"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.07.141"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.181032"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-0464"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2017.09.018"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22654"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4665-2"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-3694"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.26721","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jso.26721","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.26721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T09:01:56Z","timestamp":1693213316000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.26721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/jso.26721"],"URL":"https:\/\/doi.org\/10.1002\/jso.26721","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"2021-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}