{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:27:11Z","timestamp":1793330831206,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We evaluated the outcome of sentinel lymph node biopsies (SLNB) in patients with thin melanoma before and after the implementation of AJCC 8th edition (AJCC8) and identified predictors of positive sentinel lymph nodes (+SLN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with T1 melanomas (Breslow thickness \u22641\u2009mm) during 2016\u20132017 as per AJCC 7th edition (AJCC7) (<jats:italic>n<\/jats:italic>\u2009=\u20093414) and 2018\u20132019 as per AJCC8 (<jats:italic>n<\/jats:italic>\u2009=\u20093734) were identified in the Danish Melanoma Database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>More SLNBs were performed in the AJCC8 cohort compared to the AJCC7 (22.2% vs. 16.2%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with no significant difference in +SLN rates (4.7% vs. 6.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.118). In the AJCC7\u2009+\u2009SLN subgroup, no melanomas were ulcerated, 94.6% had mitotic rate (MR)\u2009\u2265\u20091, 67.6% were \u22650.8\u2009mm and 32.4% would be T1a according to AJCC8. In the AJCC8\u2009+\u2009SLN subgroup, 10.3% were ulcerated, 74.4% had MR\u2265\u20091, 97.4% were \u22650.8\u2009mm and 23.1% would be T1a according to AJCC7. On multivariable analysis younger age and MR\u2009\u2265\u20091 were significant predictors of +SLN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>More SLNBs were performed in T1 melanomas after transition to AJCC8 without an increase in +SLN rate. None of the AJCC8 T1b criteria were significant predictors of +SLN. We suggest that mitosis and younger age should be considered as indications for SLNB in thin melanoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26723","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T17:13:04Z","timestamp":1634836384000},"page":"498-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["More sentinel lymph node biopsies for thin melanomas after transition to AJCC 8th edition do not increase positivity rate: A Danish population\u2010based study of 7148 patients"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4452-8849","authenticated-orcid":false,"given":"Marie B.","family":"Weitemeyer","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Herlev and Gentofte University Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neel M.","family":"Helvind","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Herlev and Gentofte University Hospital Herlev Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences Copenhagen University Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Brinck","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Herlev and Gentofte University Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisbet R.","family":"H\u00f6lmich","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Herlev and Gentofte University Hospital Herlev Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences Copenhagen University Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette H.","family":"Chakera","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Herlev and Gentofte University Hospital Herlev Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences Copenhagen University Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21409"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000181092.50141.fa"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2016.05.020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(03)00275-7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.1481"},{"key":"e_1_2_10_7_1","unstructured":"The Danish Melanoma Group. 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