{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:12Z","timestamp":1786978152579,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T00:00:00Z","timestamp":1634947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Skin\u2010 and nipple\u2010sparing mastectomies (SSMs\/NSMs) present as an alternative for patients requiring mastectomy, with better aesthetic results. We aimed to evaluate the locoregional recurrence (LRR) rate and its predictive factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis of all consecutive cases of SSM and NSM for a primary diagnosis of in situ or invasive breast cancer, at a national cancer center, from January 1st, 2013 to May 31st,\u00a02019. The primary outcome was LRR. Secondary outcomes included LRR predictive factors, overall survival (OS), and disease\u2010free survival (DFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were included 461 patients; 402 (87%) with invasive carcinoma. The median age was 46 (interquartile range [IQR]: 40\u201353) years. Ninety (20%) patients had locally advanced disease. LRR rate was 3.0%, with a median follow\u2010up time of 39 (IQR: 21\u201359) months. The median time to recurrence was 22 (IQR: 10\u201345) months. Factors independently associated with LRR were high histological grade, negative estrogen receptor status, and high Ki67 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). OS was 94.8% and DFS was 92.8%. LRR was associated with decreased OS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>SSM and NSM present as a safe approach to breast cancer requiring mastectomy, including selected patients with a locally advanced tumor. The associated LRR rate is 3.0%, with risk factors being high grade, negative estrogen receptor status, and high Ki67.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.26725","type":"journal-article","created":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T10:26:40Z","timestamp":1634984800000},"page":"352-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Locoregional recurrence in skin\u2010sparing and nipple\u2010sparing mastectomies"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5934-6792","authenticated-orcid":false,"given":"Beatriz","family":"Costeira","sequence":"first","affiliation":[{"name":"Breast Surgery Unit, Department of General Surgery Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca B.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Breast Surgery Unit, Department of General Surgery Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5365-9410","authenticated-orcid":false,"given":"Rodrigo","family":"Oom","sequence":"additional","affiliation":[{"name":"Breast Surgery Unit, Department of General Surgery Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Costa","sequence":"additional","affiliation":[{"name":"Breast Surgery Unit, Department of General Surgery Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o V.","family":"Moniz","sequence":"additional","affiliation":[{"name":"Breast Surgery Unit, Department of General Surgery Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5904-6244","authenticated-orcid":false,"given":"Nuno","family":"Abecasis","sequence":"additional","affiliation":[{"name":"Breast Surgery Unit, Department of General Surgery Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina R.","family":"Santos","sequence":"additional","affiliation":[{"name":"Breast Surgery Unit, Department of General Surgery Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil  Lisbon Portugal"},{"name":"Deparment of Surgery Faculdade de Medicina da Universidade de Lisboa  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2012.12.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2016.43.4.328"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181ef8bce"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2012.12.015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.10.006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-007-9046-y"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-008-0238-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs.2016.08.01"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200208000-00013"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4737-3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5370-5"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1974-y"},{"key":"e_1_2_8_15_1","doi-asserted-by":"crossref","unstructured":"GradisharWJ LurieRH BlairSL et al. 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