{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T07:20:15Z","timestamp":1780816815708,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","award":["2167"],"award-info":[{"award-number":["2167"]}],"id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","award":["4038"],"award-info":[{"award-number":["4038"]}],"id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Optimal margins for ductal carcinoma in situ (DCIS) remain controversial in breast\u2010conserving surgery (BCS) and mastectomy. We examine the association of positive margins, reoperations, DCIS and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study of histopathological reports (4489 patients). Margin positivity was defined as ink on tumor for invasive carcinoma. For DCIS, we applied 2\u2009mm anterior and side margin thresholds, and ink on tumor in the posterior margin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of positive side margins was 20% in BCS and 5% in mastectomies (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Of these patients, 68% and 14% underwent a reoperation (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). After a positive side margin in BCS, the reoperation rates according to age groups were 74% (&lt;49), 69% (50\u201364), 68% (65\u201379), and 42% (80+) (<jats:italic>p<\/jats:italic>\u2009=\u20090.013). Of BCS patients with invasive carcinoma in the side margin, 73% were reoperated on. A reoperation was performed in 70% of patients with a close (\u22641\u2009mm) DCIS side margin, compared to 43% with a wider (1.1\u20132\u2009mm) margin (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). The reoperation rates were 55% in invasive carcinoma with close DCIS, 66% in close extensive intraductal component (EIC), and 83% in close pure DCIS (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Individual assessment as opposed to rigid adherence to guidelines was used in the decision on reoperation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26749","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T11:02:35Z","timestamp":1636974155000},"page":"577-588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Tumor margins that lead to reoperation in breast cancer: A retrospective register study of 4,489 patients"],"prefix":"10.1002","volume":"125","author":[{"given":"Maiju","family":"Lepom\u00e4ki","sequence":"first","affiliation":[{"name":"Surgery, Faculty of Medicine and Health Technology Tampere University Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Karhunen\u2010Enckell","sequence":"additional","affiliation":[{"name":"Surgery, Faculty of Medicine and Health Technology Tampere University Tampere Finland"},{"name":"Department of Surgery Tampere University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalmari","family":"Tuominen","sequence":"additional","affiliation":[{"name":"Surgery, Faculty of Medicine and Health Technology Tampere University Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauliina","family":"Kronqvist","sequence":"additional","affiliation":[{"name":"Department of Pathology Turku University Hospital Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niku","family":"Oksala","sequence":"additional","affiliation":[{"name":"Surgery, Faculty of Medicine and Health Technology Tampere University Tampere Finland"},{"name":"Vascular surgery, Vascular Centre Tampere University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teemu","family":"Murtola","sequence":"additional","affiliation":[{"name":"Surgery, Faculty of Medicine and Health Technology Tampere University Tampere Finland"},{"name":"Department of Urology, Tays Cancer Center Tampere University Hospital Tampere Finland"},{"name":"Department of Surgery Sein\u00e4joki Central Hospital Sein\u00e4joki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Roine","sequence":"additional","affiliation":[{"name":"Surgery, Faculty of Medicine and Health Technology Tampere University Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz173"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9776(09)70279-6"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(02)01012-7"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.11.029"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-020858"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6526-2"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.02.010"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2015.12.009"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2009.10.007"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.03.046"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.11.012"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5449-z"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.5182"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002439"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2008.03.007"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2018.03.008"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20242"},{"issue":"7869","key":"e_1_2_11_20_1","first-page":"18","article-title":"Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics","volume":"345","author":"Jeevan R","year":"2012","journal-title":"BMJ"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers7020815"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2018.07.056"},{"key":"e_1_2_11_23_1","volume-title":"Finnish Breast Cancer Group. 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