{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T06:14:05Z","timestamp":1778912045678,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hyperthermic intraperitoneal chemotherapy (HIPEC) during cytoreductive surgery (CRS) is typically reserved for a complete or optimal cytoreduction. There is the potential for therapeutic effect of HIPEC with an incomplete cytoreduction, particularly for near optimal cytoreductions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of incomplete cytoreductions (R2b, R2c) for appendiceal and colorectal primaries. Primary endpoints were overall survival (OS) and progression\u2010free survival (PFS). Subgroup analysis for primary etiology and specific cytoreductive score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 121 cases of incomplete CRS, 74 CRS alone, and 47 CRS\u2010HIPEC. For the entire study group there was a survival benefit with HIPEC. OS and PFS were 2.3 versus 1.4 (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) and 1.6 versus 0.7 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) respectively for cases with and without HIPEC. Subgroup analysis of appendiceal neoplasms, 43 CRS\u2010HIPEC and 50 CRS alone, found HIPEC benefit persisted; OS and PFS were 2.4 versus 1.5 (<jats:italic>p<\/jats:italic>\u2009=\u20090.016) and 1.7 versus 0.8 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), respectively for cases with and without HIPEC. Benefit most pronounced in low\u2010grade cases with doubling of the OS and PFS (<jats:italic>p<\/jats:italic>\u2009=\u20090.004). With colorectal primary cases, 10 CRS\u2010HIPEC and 18 CRS alone, no difference in OS and PFS. When stratifying out by cytoreduction scores, R2b and R2c, HIPEC only provided a benefit for R2b cases; OS and PFS for R2b cases were 2.28 versus 1.01 (<jats:italic>p<\/jats:italic>\u2009=\u20090.011) and 1.67 versus 0.75 (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), respectively for cases with and without HIPEC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HIPEC has utility for incomplete cytoreductions with appendiceal neoplasms, greatest effect with low\u2010grade appendiceal neoplasms. HIPEC is only beneficial for near optimal cytoreductions (R2b).<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26759","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T08:58:33Z","timestamp":1638176313000},"page":"703-711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Utility of hyperthermic intraperitoneal chemotherapy in cases of incomplete cytoreductive surgery"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0633-9454","authenticated-orcid":false,"given":"Christopher W.","family":"Mangieri","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology, Surgical Oncology Section Wake Forest Baptist Health Medical Center Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omeed","family":"Moaven","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic 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