{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:24:45Z","timestamp":1788200685338,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sebaceous carcinoma (SC) is a rare malignant tumour whereby, comprehensive long\u2010term data are scarce. This study aimed to assess the outcome of patients treated with resection for SC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients treated at four tertiary centres were included. Cumulative incidence curves were calculated for recurrences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 100 patients (57 males, 57%) were included with 103 SCs. The median age was 72 (range, 15\u201395) years with a median follow\u2010up of 52 (interquartile range [IQR], 24\u201093) months. Most SCs were located (peri)ocular (49.5%). Of all SCs, 17 locally recurred (16.5%) with a median time to recurrence of 19 (IQR, 8\u201329) months. The cumulative incidence probability for recurrence was statistically higher for (peri)ocular tumours (<jats:italic>p<\/jats:italic>\u2009=\u20090.005), and for positive resection margins (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). Two patients presented with lymph node metastases and additional seven patients (8.7%) developed lymph node metastases during follow\u2010up with a median time to metastases of 8 (IQR, 0.5\u201328) months. Three patients had concurrent in\u2010transit metastases and one patient also developed liver and bone metastases during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SC is a rare, yet locally aggressive tumour. Positive resection margins and (peri)ocular SCs are more frequently associated with local recurrence. SC infrequently presents with locoregional or distant metastases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26774","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T13:43:23Z","timestamp":1641476603000},"page":"730-735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Outcome after treatment for sebaceous carcinoma: A multicenter study"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5390-3719","authenticated-orcid":false,"given":"Eva Huis","family":"In 't Veld","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Keizer","sequence":"additional","affiliation":[{"name":"Department of Ocular Oncology The Rotterdam Eye Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoline","family":"Post","sequence":"additional","affiliation":[{"name":"Department of Dermatology Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Versteeg","sequence":"additional","affiliation":[{"name":"Department of Ocular Oncology The Rotterdam Eye Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Verdijk","sequence":"additional","affiliation":[{"name":"Department of Pathology,\u00a0Section Ophthalmic Pathology \u00a0Erasmus Medical Centre Rotterdam The Netherlands"},{"name":"Department of Pathology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Naus","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Erasmus Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germaine","family":"Relyveld","sequence":"additional","affiliation":[{"name":"Department of Dermatology Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Crijns","sequence":"additional","affiliation":[{"name":"Department of Dermatology Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myles","family":"Smith","sequence":"additional","affiliation":[{"name":"Sarcoma and Skin Unit, Department of Academic Surgery Royal Marsden NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Gr\u00fcnhagen","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Erasmus Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies","family":"Wakkee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erasmus Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dion","family":"Paridaens","sequence":"additional","affiliation":[{"name":"Department of Ocular Oncology The Rotterdam Eye Hospital Rotterdam The Netherlands"},{"name":"Department of Ophthalmology Erasmus Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Zavrakidis","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antien","family":"Mooyaart","sequence":"additional","affiliation":[{"name":"Department of Pathology,\u00a0Section Ophthalmic Pathology \u00a0Erasmus Medical Centre Rotterdam The Netherlands"},{"name":"Department of Pathology Erasmus Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"van Akkooi","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Strauss","sequence":"additional","affiliation":[{"name":"Sarcoma and Skin Unit, Department of Academic Surgery Royal Marsden NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis","family":"Verhoef","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Erasmus Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6173-0662","authenticated-orcid":false,"given":"Michel","family":"Wouters","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hayes","sequence":"additional","affiliation":[{"name":"Sarcoma and Skin Unit, Department of Academic Surgery Royal Marsden NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winan","family":"van Houdt","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.431"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-017-0490-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.07.046"},{"key":"e_1_2_9_5_1","unstructured":"TaiP. Stern RS Robinson JK eds. Sebaceous carcinoma \u00a0UpToDate; 2018.\u00a0"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23952"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000152"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.22009"},{"key":"e_1_2_9_9_1","unstructured":"R Core Team.R: a language and environment for statistical computing. R Foundation for Statistical Computing Vienna \u00a0Austria; 2019."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176350951"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000575"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-311533"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31829acc41"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113692"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2685"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.08.028"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-312635"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2015.79"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-018-0925-z"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01118.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-013-0547-y"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90001-2"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.22.2467"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0357-3"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000001164"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30673-4"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2004.12.008"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16552"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.09.074"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04008-y"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.26774","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jso.26774","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.26774","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T10:53:40Z","timestamp":1692788020000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.26774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,6]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/jso.26774"],"URL":"https:\/\/doi.org\/10.1002\/jso.26774","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,6]]},"assertion":[{"value":"2021-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}