{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:44:51Z","timestamp":1789706691084,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Body composition measurements using computed tomography (CT) may serve as imaging biomarkers of survival in patients with and without cancer. This study assesses whether body composition measurements obtained on abdominal CTs are independently associated with 90\u2010day and 1\u2010year mortality in patients with long\u2010bone metastases undergoing surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single institutional retrospective study included 212 patients who had undergone surgery for long\u2010bone metastases and had a CT of the abdomen within 90 days before surgery. Quantification of cross\u2010sectional areas (CSA) and CT attenuation of abdominal subcutaneous adipose tissue, visceral adipose tissue, and paraspinous and abdominal muscles were performed at L4. Multivariate Cox proportional\u2010hazards analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sarcopenia was independently associated with 90\u2010day mortality (hazard ratio [HR]\u2009=\u20091.87; 95% confidence interval [CI]\u2009=\u20091.11\u20133.16; <jats:italic>p<\/jats:italic>\u2009=\u20090.019) and 1\u2010year mortality (HR\u2009=\u20091.50; 95% CI\u2009=\u20091.02\u20132.19; <jats:italic>p<\/jats:italic>\u2009=\u20090.038) in multivariate analysis while controlling for clinical variables such as primary tumors, comorbidities, and chemotherapy. Abdominal fat CSAs and muscle attenuation were not associated with mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presence of sarcopenia assessed by CT is predictive of 90\u2010day and 1\u2010year mortality in patients undergoing surgery for long\u2010bone metastases. This body composition measurement can be used as novel imaging biomarker supplementing existing prognostic tools to optimize patient selection for surgery and improve shared decision making.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26793","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T09:32:50Z","timestamp":1642066370000},"page":"916-923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Body composition predictors of mortality in patients undergoing surgery for long bone metastases"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5091-3110","authenticated-orcid":false,"given":"Olivier Q.","family":"Groot","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery\u2014Orthopaedic Oncology Service Massachusetts General Hospital\u2014Harvard Medical School Boston Massachusetts 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