{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:50:51Z","timestamp":1771462251969,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2020J011030"],"award-info":[{"award-number":["2020J011030"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to clarify risk factors, prognostic impact, and the therapeutic value of para\u2010aortic lymph node (PALN) dissection in left\u2010sided colorectal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>One hundred and fifty\u2010four patients who underwent primary tumor resection and PALN dissection for left\u2010sided colorectal cancer were included. Logistic regression analysis was used to identify risk factors for PALN metastasis. Cox regression analysis was performed to identify risk factors for overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PALN metastasis was pathologically confirmed in 47 patients (30.5%). Postoperative complications occurred in 42 patients (27.3%). Pathological N stage (OR\u2009=\u20094.661, <jats:italic>p<\/jats:italic>\u2009=\u20090.034) and inferior mesenteric artery LNs metastasis (OR\u2009=\u20096.048, <jats:italic>p<\/jats:italic>\u2009=\u20090.003) remained to be independently associated with PALN metastasis, the 5\u2010year OS rate and median survival in patients with PALN metastasis was 37.7% and 24\u2009months. Elevated preoperative serum CA19\u20109 level (HR\u2009=\u20091.006, <jats:italic>p<\/jats:italic>\u2009=\u20090.007), number of positive LNs\u2009&gt;\u20097 (HR\u2009=\u20097.263, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), and mucinous adenocarcinoma or signet ring cell carcinoma (HR\u2009=\u20096.511, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) were independently associated with OS in patients with PALN metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PALN dissection in addition to primary tumor resection have acceptable postoperative complications and may be oncologically beneficial in selected left\u2010sided colorectal cancer patients with clinically suspicious PALN metastasis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26829","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T20:28:16Z","timestamp":1645734496000},"page":"1251-1259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Para\u2010aortic lymph node dissection in left\u2010sided colorectal cancer: Risk factors, prognostic impact, and therapeutic value"],"prefix":"10.1002","volume":"125","author":[{"given":"Yanwu","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Fujian Union Medical College Fujian Medical University  Fuzhou China"},{"name":"Department of General Surgery Fujian Medical University Union Hospital  Fuzhou China"},{"name":"Minimal Invasive Center Fujian Medical University Union Hospital  Fuzhou China"},{"name":"Fujian Medical University  Fuzhou 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