{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T17:24:55Z","timestamp":1776533095424,"version":"3.51.2"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In addition to treating hyperlipidemia and atherosclerosis, statins have demonstrated anti\u2010inflammatory and antitumor activity in various cancers. We evaluate this effect in esophageal cancer patients undergoing esophagectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Esophageal cancer patients undergoing esophagectomy at Roswell Park Comprehensive Cancer Center between March 2007 and December 2015 were included. Association between presurgery statin use and relevant variables with overall survival (OS), disease\u2010specific survival (DSS), and recurrence\u2010free survival (RFS) was analyzed using Cox hazards. Survival analyses were independently performed for body mass index (BMI)\u2010based subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant association between statin use and outcomes overall. However, in subgroup analysis, there was significant association between statin use and outcomes in patients with BMI\u2009\u2265\u200930. Multivariable analysis in obese patients demonstrated the association of statins with improved OS (hazard ratio [HR]: 0.46, <jats:italic>p<\/jats:italic>\u2009=\u20090.025), DSS (HR: 0.39, <jats:italic>p<\/jats:italic>\u2009=\u20090.015), and RFS (HR: 0.38, <jats:italic>p<\/jats:italic>\u2009=\u20090.022). The only other variable significantly associated with all three outcome measures was stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Statin use is associated with improved OS, DSS, and RFS of obese patients in resected esophageal cancer. BMI could be investigated as a biomarker for adjunctive statin use in future studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26892","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T16:29:21Z","timestamp":1651076961000},"page":"268-278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The anticancer effect of statins in obese esophageal cancer patients undergoing esophagectomy"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5503-8685","authenticated-orcid":false,"given":"Eihab","family":"Abdelfatah","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7644-4594","authenticated-orcid":false,"given":"Moshim","family":"Kukar","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarbajit","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrienne","family":"Groman","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sai","family":"Yendamuri","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v6.i5.112"},{"key":"e_1_2_8_3_1","volume-title":"Radiation Therapy, Chemoradiotherapy, Neoadjuvant Approaches, and Postoperative Adjuvant Therapy for Localized Cancers of the Esophagus","author":"Gibson MK","year":"2020"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra035010"},{"issue":"1","key":"e_1_2_8_5_1","first-page":"10","article-title":"The statins as anticancer agents","volume":"9","author":"Chan KK","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_8_6_1","unstructured":"National Ambulatory Medical Care Survey. 2016 National Summary Tables. 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