{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:27:42Z","timestamp":1747150062374,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPG3H0483"],"award-info":[{"award-number":["CMRPG3H0483"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study investigated the long\u2010term effects of arterial ischemia and venous occlusion on lymph node drainage function in a rat model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Bilateral groin lymph node flaps of 18 Lewis rats were dissected. The pedicle artery was clamped for 4, 5, and 6\u2009h (A4, A5, and A6 groups), and the vein for 3, 4, and 5\u2009h (V3, V4, and V5 groups) in six flaps. At 4 weeks, the evaluations included gross morphomics, indocyanine green (ICG) lymphography, histological section, immunofluorescence of terminal deoxynucleotidyl transferase assay, and heme oxygenase\u20101 (HO\u20101) stain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The lymph node flaps developed shrinkage and partial necrosis in A5, A6, V4, and V5 groups. Hemorrhage in the lymph node cortex and medulla was observed histologically in A5, A6, and V5 groups. ICG lymphography showed loss of lymphatic drainage function in 2 of 6 flaps in A6 and V5 groups. Cell death was shown partly in cortical follicles in A5 and V4 groups and completely in A6 and V5 groups. The HO\u20101 expression was statistically increased in A5 and V5 groups, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The critical arterial ischemia and venous occlusion time were 4\u2009h at 4 weeks of follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26980","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T14:25:21Z","timestamp":1654784721000},"page":"633-639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010term outcomes of arterial ischemia or venous occlusion on vascularized groin lymph nodes in a rat model"],"prefix":"10.1002","volume":"126","author":[{"given":"Chin\u2010Yu","family":"Yang","sequence":"first","affiliation":[{"name":"Center for Tissue Engineering Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines E.","family":"Tinhofer","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery Hospital of Divine Savior Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4237-2959","authenticated-orcid":false,"given":"Ming\u2010Huei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Center for Tissue Engineering Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital Chang Gung University and Medical College Taoyuan Taiwan"},{"name":"Center for Lymphedema Microsurgery Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"Division of Plastic Surgery Ann The University of Michigan Arbor Michigan 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