{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:44:08Z","timestamp":1788288248863,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T00:00:00Z","timestamp":1654905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Applicability of the albumin\u2010bilirubin (ALBI) grade in preoperative decision\u2010making criteria based on the indocyanine green retention (ICG) test remains unclear. This study aimed to predict abnormal ICG values using standard blood tests and evaluate the impact on postoperative outcomes among patients undergoing hepatectomy for hepatocellular carcinoma (HCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on 949 consecutive HCC patients undergoing curative\u2010intent hepatectomy between 1996 and 2014 were retrospectively assessed. A nomogram using preoperative standard blood tests was created to predict abnormal ICGR15 (&gt;15%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three\u2010hundred nine patients had abnormal ICGR15. Predictors of abnormal ICGR15 included in the nomogram were: ALBI grade &gt;1 (hazard ratio [HR]: 2.16, 95% confidence interval [CI]: 1.59\u20132.94), platelet count &lt;130\u2009000\/mm<jats:sup>3<\/jats:sup> (HR: 2.27, 95% CI: 1.68\u20133.08), aspartate aminotransferase &gt;50 (IU\/L) (HR: 1.90, 95% CI: 1.29\u20132.81), and viral hepatitis infection (HR: 1.46, 95% CI: 1.03\u20132.07). The nomogram named the PLT\u2010ALBI score was discriminative [C\u2010statistics: 0.719 (0.684\u20130.754)], and reliable (Hosmer\u2010Lemeshow Chi\u2010Square: 9.05, <jats:italic>p<\/jats:italic>\u2009=\u20090.338). The higher PLT\u2010ALBI score was associated with a more frequent incidence of clinically relevant posthepatectomy liver failure and poor overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The PLT\u2010ALBI score is applicable in distinguishing HCC patients with abnormal ICGR15. Patients with higher PLT\u2010ALBI score require more careful postoperative care, despite following the ICG criteria.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.26982","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T12:53:01Z","timestamp":1654951981000},"page":"680-688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Application of albumin\u2010bilirubin grade and platelet count to indocyanine green\u2010based criteria for hepatectomy: Predicting impaired liver function and postoperative outcomes of hepatocellular carcinoma"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0455-6412","authenticated-orcid":false,"given":"Takeshi","family":"Takamoto","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery National Cancer Center Hospital  Tokyo 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