{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T16:37:57Z","timestamp":1781800677670,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Type II diabetes mellitus (T2DM) can lead to an immunosuppressed state, but whether T2DM is associated with worse outcomes for patients with melanoma has not been well studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients diagnosed with clinical stage I\u2013II cutaneous melanoma who underwent sentinel lymph node biopsy at a single institution (2007\u20132016) were identified. Melanoma characteristics and recurrence\/survival outcomes were compared between patients with and without T2DM at the time of melanoma diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1128 patients evaluated, 111 (9.8%) had T2DM (<jats:italic>n<\/jats:italic>\u2009=\u200994 [84.7%] non\u2010insulin dependent [NID\u2010T2DM]; <jats:italic>n<\/jats:italic>\u2009=\u200917 [15.3%] insulin dependent [ID\u2010T2DM]). T2DM patients were more likely to be older (odds ratio [OR] 1.04, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), male (OR 2.15, <jats:italic>p<\/jats:italic>\u2009=\u20090.003), have tumors &gt;1.0\u2009mm (OR 1.88, <jats:italic>p<\/jats:italic>\u2009=\u20090.023), and have microsatellitosis (OR 2.29, <jats:italic>p<\/jats:italic>\u2009=\u20090.030). Five\u2010year cumulative incidence of melanoma recurrence was significantly higher for patients with ID\u2010T2DM (46.7% ID\u2010T2DM vs. 25.7% NID\u2010T2DM vs. 17.1% no T2DM, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and on multivariable analysis, ID\u2010T2DM was independently associated with melanoma recurrence (hazard ratio 2.57, <jats:italic>p<\/jats:italic>\u2009=\u20090.015). No difference in 5\u2010year disease\u2010specific survival was observed between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ID\u2010T2DM\u202fappears to be associated with more advanced melanoma and increased risk for melanoma recurrence. Further study as to whether this reflects differences in tumor biology or host factors is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27021","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T11:44:12Z","timestamp":1659008652000},"page":"1263-1271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of type II diabetes mellitus with characteristics and outcomes for patients undergoing sentinel lymph node biopsy for cutaneous melanoma"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2263-3576","authenticated-orcid":false,"given":"Richard J.","family":"Straker","sequence":"first","affiliation":[{"name":"Department of Surgery, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella N.","family":"Tortorello","sequence":"additional","affiliation":[{"name":"Department of Surgery, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8398-3297","authenticated-orcid":false,"given":"Cimarron E.","family":"Sharon","sequence":"additional","affiliation":[{"name":"Department of Surgery, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke J.","family":"Keele","sequence":"additional","affiliation":[{"name":"Department of Surgery, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Y.","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Surgery, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgos C.","family":"Karakousis","sequence":"additional","affiliation":[{"name":"Department of Surgery, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Ming","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.3048"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.04.018"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.19"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)61032-X"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399815666191024085838"},{"issue":"7","key":"e_1_2_10_9_1","first-page":"857","article-title":"Type 2 diabetes mellitus and risk of malignant melanoma: a systematic review and meta\u2010analysis of cohort studies","volume":"43","author":"Qi 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