{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T12:42:48Z","timestamp":1789216968751,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Resection of colorectal liver metastasis (CLM) is beneficial when feasible. However, the benefit of second hepatectomy for hepatic recurrence in CLM remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Colorectal Liver Operative Metastasis International Collaborative retrospectively examined 1004 CLM cases from 2000 to 2018 from a total of 953 patients. Hepatic recurrence after initial hepatectomy was identified in 218 patients. Kaplan\u2013Meier analysis was performed for overall survival (OS) and recurrence\u2010free survival (RFS). Propensity score matching (PSM) was performed to offset selection bias. Cox proportional\u2010hazards regression was performed to identify risk factors associated with OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 51 patients underwent second hepatectomy. Unadjusted median OS was 60.1 months in repeat\u2010hepatectomy versus 38.3 months in the single\u2010hepatectomy group (<jats:italic>p<\/jats:italic>\u2009=\u20090.015). In the PSM population, median OS remained significantly better in the repeat\u2010hepatectomy group (60.1 vs. 33.1 months; <jats:italic>p<\/jats:italic>\u2009=\u20090.0023); median RFS was 12.4 months for the repeat\u2010hepatectomy group, versus 9.8 months in the single\u2010hepatectomy group (<jats:italic>p<\/jats:italic>\u2009=\u20090.0050). Repeat hepatectomy was associated with lower risk of death (hazard ratio: 0.283; <jats:italic>p<\/jats:italic>\u2009=\u20090.000012). Obesity, tobacco use, and high intraoperative blood loss were associated with significant risk of death (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In CLM with hepatic recurrence, second hepatectomy was beneficial for OS. With PSM, the OS benefit of performing a second hepatectomy remained significant.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27056","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T14:03:35Z","timestamp":1660572215000},"page":"1242-1252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Outcomes after repeat hepatectomy for colorectal liver metastases from the colorectal liver operative metastasis international collaborative (COLOMIC)"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8694-9174","authenticated-orcid":false,"given":"Cristian D.","family":"Valenzuela","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology, Comprehensive Cancer Center Atrium Health Wake Forest Baptist Medical Center Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0560-0457","authenticated-orcid":false,"given":"Omeed","family":"Moaven","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Comprehensive Cancer Center Atrium Health Wake Forest Baptist Medical Center Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohin","family":"Gawdi","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Comprehensive Cancer Center Atrium Health Wake Forest Baptist Medical Center Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Stauffer","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Mayo Clinic in Florida Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico R.","family":"Del Piccolo","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Mayo Clinic in Florida Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tan To","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos U.","family":"Corvera","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary &amp; 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