{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T04:42:49Z","timestamp":1775968969583,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In patients with low\u2010grade appendiceal mucinous neoplasms (LAMN), a secondary cytoreductive surgery (SCRS) is often performed if recurrent disease is detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In patients with a complete cytoreductive surgery (CRS), the clinical\u2010 and treatment\u2010related variables associated with the index CRS and the SCRS were statistically assessed for their impact on overall survival after SCRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010eight patients of 450 patients (19.6%) had SCRS. The mean survival was 15.3 years for patients requiring SCRS as compared to 24.5 years for the group as a whole. Variables associated with improved survival as a result of the index CRS by multivariant modeling were absence of total gastrectomy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0038), moderate peritoneal cancer index of 15\u201330 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0020) and time interval of greater than 36 months from CRS to SCRS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0013). Multivariant modeling associated with SCRS were complete CRS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0104) and disease progression limited to the abdominal wall (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0106). Early postoperative intraperitoneal chemotherapy (EPIC) 5\u2010fluorouracil used with CRS improved the outcome with SCRS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0095).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      A requirement for SCRS in 88 patients decreased median survival to 15.3 years as compared to 24.5 years in all 450 LAMN patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Prognostic indicators from both the index CRS and the SCRS had an impact on the outcome of SCRS.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.27064","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T06:58:30Z","timestamp":1660719510000},"page":"1451-1461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Secondary cytoreductive surgery for low\u2010grade appendiceal mucinous neoplasms"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2431-7366","authenticated-orcid":false,"given":"Paul H.","family":"Sugarbaker","sequence":"first","affiliation":[{"name":"Program in Peritoneal Surface Malignancy, Department of Surgery MedStar Washington Hospital Center Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Chang","sequence":"additional","affiliation":[{"name":"Westat Rockville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V22122"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1994.74.1.163"},{"key":"e_1_2_8_4_1","first-page":"1","article-title":"Pharmacokinetic rationale for peritoneal drug administration in the treatment of ovarian cancer","volume":"62","author":"Dedrick RL","year":"1978","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.7.480"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/026567399285765"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880115)61:2<232::AID-CNCR2820610205>3.0.CO;2-U"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990201)85:3<529::AID-CNCR3>3.0.CO;2-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00348209"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9487-4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199501000-00004"},{"issue":"1","key":"e_1_2_8_12_1","article-title":"Sugarbaker procedure for pseudomyxoma peritonei","volume":"2006","author":"Nagarajan P","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199502000-00002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70539-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9462-0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000535"},{"issue":"1","key":"e_1_2_8_17_1","first-page":"49","article-title":"Current methodologies for clinical assessment of patients with peritoneal carcinomatosis","volume":"15","author":"Jacquet P","year":"1996","journal-title":"J Exp Clin Cancer Res"},{"key":"e_1_2_8_18_1","first-page":"47","volume-title":"Cytoreductive Surgery & Perioperative Chemotherapy for Peritoneal Surface Malignancy. 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