{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:38:56Z","timestamp":1789961936253,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatic epithelioid hemangioendothelioma (HEH) is a rare vascular tumor of unknown etiology and unpredictable natural history. To date, no large\u2010scale studies have been published evaluating this disease due to its rare occurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The National Cancer Database was reviewed between 2004 and 2016 to identify patients with HEH. Univariate analysis with overall survival (OS) was performed by Cox proportional hazards model. Kaplan\u2013Meier method was used to create OS curves and compared using the log\u2010rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 229 patients with HEH. The majority of patients were female (61.1%), white (84.3%), and had a Charlson\u2013Deyo score of 0 (75%). Chemotherapeutic intervention was seen in 26% of the patients while 33% received surgical intervention in the form of wedge\/segmental liver resection (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200927), hepatectomy lobectomy\/extended lobectomy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918), and liver transplant (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922). Five\u2010year survival in surgical patients was 90.5%, 66.5% and 81%, respectively\u00a0(\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.485). Age greater than 55 years (hazard ratio [HR], 2.78;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), Asian ethnicity compared to white (HR, 2.84;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012), and a higher Charlson\u2013Deyo score (score 1: HR,\u00a02.28;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 and score \u22652: HR, 2.76;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011) were associated with worse OS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Treatment for HEH remains variable with only a third of the patients undergoing surgery. International collaboration is necessary to determine the optimal treatment for this rare disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.27066","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T05:39:58Z","timestamp":1660714798000},"page":"1423-1429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A review of hepatic epithelioid hemangioendothelioma\u2014Analyzing patient characteristics and treatment strategies"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9292-8345","authenticated-orcid":false,"given":"Pranay S.","family":"Ajay","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileios","family":"Tsagkalidis","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Rochester School of Medicine and Dentistry  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Casabianca","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Rochester School of Medicine and Dentistry  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7370-5608","authenticated-orcid":false,"given":"Paul R.","family":"Burchard","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Rochester School of Medicine and Dentistry  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa D.","family":"Melucci","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Rochester School of Medicine and Dentistry  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Chacon","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Rochester School of Medicine and Dentistry  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subir","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Rollins School of Public Health Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Switchenko","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Rollins School of Public Health Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8694-0455","authenticated-orcid":false,"given":"David A.","family":"Kooby","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Winship Cancer Institute, Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren R.","family":"Carpizo","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Wilmot Caner Center University of Rochester School of Medicine and Dentistry  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4665-5534","authenticated-orcid":false,"given":"Mihir M.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Winship Cancer Institute, Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(86)90204-5"},{"key":"e_1_2_9_3_1","first-page":"529","article-title":"Epithelioid hemangioendothelioma of the heart with distant metastases. 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