{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T04:42:55Z","timestamp":1775968975253,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study sought to determine the R0 resection rate in KRAS wild\u2010type (WT), liver\u2010only metastatic colorectal cancer\u00a0(CRC) patients initially identified as having unresectable disease who were treated with FOLFOX7 plus cetuximab. Exploratory molecular analyses were undertaken before and after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty patients were enrolled. None had prior adjuvant chemotherapy. Cetuximab was added to a FOLFOX7 backbone and administered at 500\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      every 14 days with dose reductions to 400 and 300\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      in the event of toxicity. In the absence of toxicity, dose\u2010escalations to 600, 700, and 800\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      were allowed. The mean dose of cetuximab (mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      \/week) throughout the study was 289\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Paired samples were collected for correlative studies, where feasible.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We assessed the conversion rates from unresectable to resectable in hepatic\u2010only, KRAS exon 2 WT mCRC. Seventeen of 20 patients undergoing chemotherapy were considered resectable by imaging criteria; R0 resection was achieved in 15\/20 patients. Molecular profiling revealed heterogeneity between patients at the gene\u2010expression, pathway signaling, and immune\u2010profile levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although 15\/20 (75%) converted to R0 resection, by 2 years, 10\/15 R0 resections had recurred. Therefore, chemotherapy plus cetuximab is of limited long\u2010term benefit in this setting. ctDNA analysis may guide additional therapy including immunotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.27078","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T04:08:56Z","timestamp":1663301336000},"page":"1494-1503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NSABP FC\u20106: Surgical conversion rate in colorectal cancer patients with unresectable, KRAS wild\u2010type liver metastases receiving mFOLFOX7 plus cetuximab"],"prefix":"10.1002","volume":"126","author":[{"given":"Lawrence D.","family":"Wagman","sequence":"first","affiliation":[{"name":"Department of Medicine NSABP Foundation Pittsburgh PA"},{"name":"Department of Surgery\/Oncology City of Hope Orange CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David 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