{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:27:36Z","timestamp":1740104856798,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T00:00:00Z","timestamp":1663372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008457","name":"University of Virginia","doi-asserted-by":"publisher","award":["Farrow Fellowship","Rebecca Clary Harris Memorial Fellowship"],"award-info":[{"award-number":["Farrow Fellowship","Rebecca Clary Harris Memorial Fellowship"]}],"id":[{"id":"10.13039\/100008457","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Completion lymph node dissection (CLND) for microscopic lymph node metastases has been replaced by observation; however, CLND is standard for clinically detectable nodal metastases (cLN). CLND has high morbidity, which may be reduced by excision of only the cLN (precision lymph node dissection [PLND]). We hypothesized that same\u2010basin recurrence risk would be low after PLND.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review at four tertiary care hospitals identified patients who underwent PLND. The primary outcome was 3\u2010year cumulative incidence of isolated same\u2010basin recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010one patients underwent PLND for cLN without synchronous distant metastases. Reasons for forgoing CLND included patient preference (<jats:italic>n<\/jats:italic>\u2009=\u200911), comorbidities (<jats:italic>n<\/jats:italic>\u2009=\u20095), imaging indeterminate for distant metastases (<jats:italic>n<\/jats:italic>\u2009=\u20092), partial response to checkpoint blockade (<jats:italic>n<\/jats:italic>\u2009=\u20091), or not reported (<jats:italic>n<\/jats:italic>\u2009=\u20092). A median of 2 nodes (range: 1\u20136) were resected at PLND, and 68% contained melanoma. Recurrence was observed in 33% overall. Only 1 patient (5%) developed an isolated same\u2010basin recurrence. Cumulative incidences at 3 years were 5.0%, 17.3%, and 49.7% for isolated same\u2010basin recurrence, any same\u2010basin recurrence, and any recurrence, respectively. Complications from PLND were reported in 1 patient (5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These pilot data suggest that PLND may provide adequate regional disease control with less morbidity than CLND. These data justify prospective evaluation of PLND in select patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27100","type":"journal-article","created":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T16:39:18Z","timestamp":1663432758000},"page":"140-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Regional control after precision lymph node dissection for clinically evident melanoma metastasis"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9845-6617","authenticated-orcid":false,"given":"Kevin T.","family":"Lynch","sequence":"first","affiliation":[{"name":"Department of Surgery University of Virginia Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Maryland Baltimore Maryland 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