{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T15:55:24Z","timestamp":1772207724525,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Despite the standard interval of 6\u22128 weeks between neoadjuvant chemoradiotherapy (nCRT) and surgery, it is debated whether an interval of &gt;8 weeks increases the pathologic complete response (pCR) rate. We investigated the interval between nCRT and surgery, and its impact on oncological outcomes and postoperative complications in patients with locally advanced rectal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed patients with rectal cancer who underwent total mesorectal excision after long\u2010course nCRT between 2000 and 2020. They were divided into two groups\u2014those who underwent surgery at 6\u22128 and &gt;8 weeks after nCRT. Surgical outcomes (stoma rate and postoperative complications), pCR, tumor regression grade (TRG), recurrence\u2010free survival (RFS), and overall survival (OS) were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We selected 770\/1153 patients with rectal cancer, including 502 and 268 patients surgically treated at 6\u22128 and &gt;8 weeks after nCRT, respectively. The pCR rates were similar between the two groups (14.7% vs. 15.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.836), while the TRG was significantly better in the &gt;8 weeks group (<jats:italic>p<\/jats:italic>\u2009=\u20090.267). Additionally, the postoperative complications, recurrence, 5\u2010year RFS, and OS rates were not significantly different between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although tumor regression increased in the &gt;8 weeks group, the oncological benefits of surgery &gt;8 weeks after nCRT remain uncertain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27105","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T11:20:12Z","timestamp":1664364012000},"page":"119-131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Standard versus longer interval of radical resection after neoadjuvant chemoradiotherapy in locally advanced rectal cancer: A 20\u2010year single\u2010center experience &amp; propensity\u2010score matching"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6975-7541","authenticated-orcid":false,"given":"Saule","family":"Khamzina","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery Multidisciplinary City Hospital N1  Nur\u2010Sultan Kazakhstan"},{"name":"Department of Surgery National Research Oncology Center  Nur\u2010Sultan Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jongoh","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery Department of Surgery, Seoul National University Hospital, Seoul National University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6407-0444","authenticated-orcid":false,"given":"Seung\u2010Bum","family":"Ryoo","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery Department of Surgery, Seoul National University Hospital, Seoul National University College of Medicine  Seoul Korea"},{"name":"Colorectal Cancer Center, Seoul National University Cancer Hospital  Seoul Korea"},{"name":"Cancer Research Institute Seoul National University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery Department of Surgery, Seoul National University Hospital, Seoul National University College of Medicine  Seoul Korea"},{"name":"Colorectal Cancer Center, Seoul National University Cancer Hospital  Seoul Korea"},{"name":"Cancer Research Institute Seoul National University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-8175","authenticated-orcid":false,"given":"Ji Won","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery Department of Surgery, Seoul National University Hospital, Seoul National University College of Medicine  Seoul Korea"},{"name":"Colorectal Cancer Center, Seoul National University Cancer Hospital  Seoul Korea"},{"name":"Cancer Research Institute Seoul National University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun\u2010Cheol","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Seoul National University Hospital, Seoul National University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eui Kyu","family":"Chie","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Seoul National University Hospital, Seoul National University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae\u2010Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Hematooncology Department of Internal Medicine,\u00a0Seoul National University 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