{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T03:01:43Z","timestamp":1775617303963,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["T32CA106183"],"award-info":[{"award-number":["T32CA106183"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The primary aim of this study is to evaluate the oncologic outcomes of two popular systemic chemotherapy approaches in patients with colorectal peritoneal metastases\u00a0(CPM) undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS\u2010HIPEC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a dual\u2010center retrospective review of consecutive patients who underwent CRS\u2010HIPEC for CPM due to high or intermediate\u2010grade colorectal cancer. Patients in the total neoadjuvant therapy (TNT) group received 6 months of preoperative chemotherapy. Patients in the \u201csandwich\u201d (SAND) chemotherapy group received 3 months of preoperative chemotherapy with a maximum of 3 months of postoperative chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 34 (43%) patients were included in the TNT group and 45 (57%) patients in the SAND group. The median overall survival (OS) in the TNT and SAND groups were 77 and 61 months, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.8). Patients in the TNT group had significantly longer recurrence\u2010free survival\u00a0(RFS) than the SAND group (29 vs. 12 months, <jats:italic>p<\/jats:italic>\u2009=\u20090.02). In a multivariable analysis, the\u00a0TNT approach was independently associated with improved RFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this retrospective study, a TNT approach was associated with improved RFS, but not OS when compared with a SAND approach. Further prospective studies are needed to examine these systemic chemotherapeutic approaches in patients with CPM undergoing CRS\u2010HIPEC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27136","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T13:37:01Z","timestamp":1668001021000},"page":"442-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A total neoadjuvant chemotherapy approach is associated with improved recurrence\u2010free survival in patients with colorectal peritoneal metastases undergoing cytoreductive surgery and HIPEC"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2530-0328","authenticated-orcid":false,"given":"David N.","family":"Hanna","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology and Endocrine Surgery, Section of Surgical Sciences\u00a0 Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6624-4735","authenticated-orcid":false,"given":"Rebekah","family":"Macfie","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology Icahn School of Medicine at Mount Sinai University New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad O.","family":"Ghani","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology and Endocrine Surgery, Section of Surgical Sciences\u00a0 Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Hermina","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology and Endocrine Surgery, Section of Surgical Sciences\u00a0 Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Mina","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da Eun","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology Icahn School of Medicine at Mount Sinai University New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina E.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology and Endocrine Surgery, Section of Surgical Sciences\u00a0 Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology Icahn School of Medicine at Mount Sinai University New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Labow","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology Icahn School of Medicine at Mount Sinai University New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Golas","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology Icahn School of Medicine at Mount Sinai University New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umut","family":"Sarpel","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology Icahn School of Medicine at Mount Sinai University New York City New York 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