{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T11:01:12Z","timestamp":1776250872520,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773460"],"award-info":[{"award-number":["81773460"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intraductal papillary mucinous neoplasms (IPMNs) have the potential to become malignant. Few studies have focused on the prevalence of the diabetes mellitus (DM) in IPMNs and its association with malignancy. We evaluated the association between DM and malignant IPMNs in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 226 patients with pathologically confirmed IPMNs were included. Demographic data, serum biochemical data, and imaging findings were collected. The malignant IPMNs were defined as those with high\u2010grade dysplasia and associated invasive carcinoma. The association between DM and malignant IPMNs was studied using logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of DM was 17.7% for all type IPMNs and 31.7% for malignant IPMNs. Compared to patients without DM, those with DM had a 3.6\u2010fold (odds ratio [OR]: 3.62; 95% confidence interval [CI]: 1.26\u201310.44) higher risk of invasive carcinoma and 2.5\u2010fold (OR: 2.48; 95% CI: 1.06\u20135.77) higher risk of malignant IPMNs. Similar results were observed in main pancreatic duct (MPD) involved IPMNs. New\u2010onset DM was associated with a 4.13\u2010fold (OR: 4.13, 95% CI: 1.27\u201313.36) higher risk of invasive carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DM is associated with a higher risk of malignant IPMNs and invasive carcinoma, especially in patients with MPD\u2010involved IPMNs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27142","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T13:58:05Z","timestamp":1669039085000},"page":"625-632","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diabetes in intraductal papillary mucinous neoplasm of the pancreas and its association with malignancy"],"prefix":"10.1002","volume":"127","author":[{"given":"Hao","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Radiology Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 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