{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:16:15Z","timestamp":1774440975423,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T00:00:00Z","timestamp":1669420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>We examined the effect of disease\u2010free interval (DFI) duration on cancer\u2010specific mortality (CSM)\u2010free survival, otherwise known as the effect of conditional survival, in surgically treated adrenocortical carcinoma (ACC) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Within the Surveillance, Epidemiology, and End Results database (2004\u22122018), 867 ACC patients treated with adrenalectomy were identified. Conditional survival estimates at 5\u2010years were assessed based on DFI duration and according to stage at presentation. Separate Cox regression models were fitted at baseline and according to DFI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 406 (47%), 285 (33%), and 176 (20%) patients were stage I\u2212II, III and IV, respectively. In conditional survival analysis, providing a DFI of 24 months, 5\u2010year CSM\u2010free survival at initial diagnosis increased from 66% to 80% in stage I\u2212II, from 35% to 66% in stage III, and from 14% to 36% in stage IV. In multivariable Cox regression models, stage III (hazard ratio [HR]: 2.38;\u00a0<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and IV (HR: 4.67;\u00a0<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) independently predicted higher CSM, relative to stage I\u2212II. The magnitude of this effect decreased over time, providing increasing DFI duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In surgically treated ACC, survival probabilities increase with longer DFI duration. This improvement is more pronounced in stage III, followed by stages IV and I\u2212II patients, in that order. Survival estimates accounting for DFI may prove valuable in patients counseling.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27161","type":"journal-article","created":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T18:33:22Z","timestamp":1669487602000},"page":"560-567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Contemporary conditional cancer\u2010specific survival rates in surgically treated adrenocortical carcinoma patients: A stage\u2010specific analysis"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9756-4632","authenticated-orcid":false,"given":"Andrea","family":"Panunzio","sequence":"first","affiliation":[{"name":"Department of Urology, Azienda Ospedaliera Universitaria Integrata di Verona University of Verona  Verona Italy"},{"name":"Division of Urology, Cancer Prognostics and Health Outcomes Unit University of Montr\u00e9al Health Center  Montr\u00e9al, Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Barletta","sequence":"additional","affiliation":[{"name":"Division of Urology, Cancer Prognostics and Health Outcomes Unit University of Montr\u00e9al Health Center  Montr\u00e9al, Qu\u00e9bec Canada"},{"name":"Department of Urology and Division of Experimental Oncology, URI, Urological Research Institute IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Tappero","sequence":"additional","affiliation":[{"name":"Division of Urology, Cancer Prognostics and Health Outcomes Unit University of Montr\u00e9al Health Center  Montr\u00e9al, Qu\u00e9bec Canada"},{"name":"Department of Surgical and Diagnostic Integrated Sciences (DISC) University of Genova  Genova Italy"},{"name":"Department of Urology IRCCS Policlinico San Martino  Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Cano Garcia","sequence":"additional","affiliation":[{"name":"Division of Urology, Cancer Prognostics and Health Outcomes Unit University of Montr\u00e9al Health Center  Montr\u00e9al, Qu\u00e9bec Canada"},{"name":"Department of Urology University Hospital Frankfurt  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Piccinelli","sequence":"additional","affiliation":[{"name":"Division of Urology, Cancer Prognostics and Health Outcomes Unit University of Montr\u00e9al Health Center  Montr\u00e9al, Qu\u00e9bec Canada"},{"name":"Department of Urology, IEO European Institute of Oncology IRCCS  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reha\u2010Baris","family":"Incesu","sequence":"additional","affiliation":[{"name":"Division of Urology, Cancer Prognostics and Health Outcomes Unit University of Montr\u00e9al Health Center  Montr\u00e9al, Qu\u00e9bec Canada"},{"name":"Martini\u2010Klinik Prostate Cancer Center University Hospital Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle W.","family":"Law","sequence":"additional","affiliation":[{"name":"Division of Urology, Cancer Prognostics and Health Outcomes Unit University of Montr\u00e9al Health Center  Montr\u00e9al, Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Tian","sequence":"additional","affiliation":[{"name":"Division of Urology, Cancer Prognostics and Health Outcomes Unit University of Montr\u00e9al Health Center  Montr\u00e9al, Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Tafuri","sequence":"additional","affiliation":[{"name":"Department of Urology, Azienda Ospedaliera Universitaria Integrata di Verona University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya","family":"Tilki","sequence":"additional","affiliation":[{"name":"Martini\u2010Klinik Prostate Cancer Center University Hospital Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Department of Urology University Hospital Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Department of Urology Koc University Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ottavio","family":"De Cobelli","sequence":"additional","affiliation":[{"name":"Department of Urology, IEO European Institute of Oncology IRCCS  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix K. H.","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospital Frankfurt  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Terrone","sequence":"additional","affiliation":[{"name":"Department of Surgical and Diagnostic Integrated Sciences (DISC) University of Genova  Genova Italy"},{"name":"Department of Urology IRCCS Policlinico San Martino  Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Briganti","sequence":"additional","affiliation":[{"name":"Department of Urology and Division of Experimental Oncology, URI, Urological Research Institute IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Saad","sequence":"additional","affiliation":[{"name":"Division of Urology, Cancer Prognostics and Health Outcomes Unit University of Montr\u00e9al Health Center  Montr\u00e9al, Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahrokh F.","family":"Shariat","sequence":"additional","affiliation":[{"name":"Department of Urology, Comprehensive Cancer Center Medical University of Vienna  Vienna Austria"},{"name":"Departments of Urology Weill Cornell Medical College  New York New York USA"},{"name":"Department of Urology University of Texas Southwestern  Dallas Texas USA"},{"name":"Hourani Center for Applied Scientific Research Al\u2010Ahliyya Amman University  Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Bourdeau","sequence":"additional","affiliation":[{"name":"Department of Medicine and Research Center, Division of Endocrinology Centre hospitalier de l'Universit\u00e9 de Montreal (CHUM)  Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Cerruto","sequence":"additional","affiliation":[{"name":"Department of Urology, Azienda Ospedaliera Universitaria Integrata di Verona University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Department of Urology, Azienda Ospedaliera Universitaria Integrata di Verona University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre I.","family":"Karakiewicz","sequence":"additional","affiliation":[{"name":"Division of Urology, Cancer Prognostics and Health Outcomes Unit University of Montr\u00e9al Health Center  Montr\u00e9al, Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2013-1029"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e3283602274"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-18-0608"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-021-01618-0"},{"issue":"10","key":"e_1_2_10_6_1","first-page":"2817","article-title":"Prognostic factors of adrenocortical carcinoma: an analysis of the surveillance epidemiology and end results (SEER) database","volume":"18","author":"Wang S","year":"2017","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3164-6"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.06.024"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.08.014"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-011-0876-6"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481307901033"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.08.047"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2019.05.020"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2019.7350"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.7568"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.521"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25877"},{"key":"e_1_2_10_18_1","unstructured":"About the SEER Program. 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