{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T02:47:00Z","timestamp":1784515620007,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to define how utilization of plastic surgical reconstruction (PSR) affects perioperative outcomes, locoregional recurrence\u2010free survival (LRRFS), and overall survival (OS) after radical resection of extremity and truncal soft tissue sarcoma (ETSTS). The secondary aim was to determine factors associated with PSR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent resection of ETSTS between 2000 and 2016 were identified from a multi\u2010institutional database. PSR was defined as complex primary closure requiring a plastic surgeon, skin graft, or tissue\u2010flap reconstruction. Outcomes included PSR utilization, postoperative complications, LRRFS, and OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2750 distinct operations, 1060 (38.55%) involved PSR. Tissue\u2010flaps (854, 80.57%) were most commonly utilized. PSR was associated with a higher proportion of R0 resections (83.38% vs. 74.42%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Tissue\u2010flap PSR was associated with local wound complications (odds ratio: 1.81, confidence interval: 1.21\u20132.72, <jats:italic>p<\/jats:italic>\u2009=\u20090.004). Neither PSR nor postoperative complications were independently associated with LRRFS or OS. High\u2010grade tumors (1.60, 1.13\u20132.26, <jats:italic>p<\/jats:italic>\u2009=\u20090.008) and neoadjuvant radiation (1.66, 1.20\u20132.30, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) were associated with the need for PSR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with ETSTS undergoing resection with PSR experienced acceptable rates of complications and a higher rate of negative margins, which were associated with improved LRRFS and OS. High tumor grade and neoadjuvant radiation were associated with requirement of PSR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27169","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T16:17:26Z","timestamp":1670429846000},"page":"550-559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Outcomes of plastic surgical reconstruction in extremity and truncal soft tissue sarcoma:\u00a0Results from the US Sarcoma Collaborative"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2681-2109","authenticated-orcid":false,"given":"Sam Z.","family":"Thalji","sequence":"first","affiliation":[{"name":"Department of Surgery Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia G.","family":"Ethun","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Winship Cancer 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