{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:35:26Z","timestamp":1769754926061,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>There is a paucity of evidence on the value of intraperitoneal chemotherapy (IPC) following cytoreductive surgery (CRS) for colorectal peritoneal metastasis. This study aimed to evaluate the association between mitomycin C\u2010IPC and survival outcomes following CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The institutional databases of two tertiary hospitals were reviewed to identify patients who underwent CRS for colorectal peritoneal metastasis. The outcomes of patients who underwent CRS without IPC were compared with those of patients who underwent CRS plus early postoperative intraperitoneal chemotherapy\u00a0(EPIC) or CRS plus hyperthermic intraperitoneal chemotherapy\u00a0(HIPEC). The primary endpoints were cancer\u2010specific survival (CSS), progression\u2010free survival (PFS), and peritoneal PFS (P\u2010PFS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 149 patients with peritoneal metastasis alone, EPIC and HIPEC use was significantly associated with better CSS, PFS, and P\u2010PFS in the multivariate analysis. CSS was also significantly associated with perioperative systemic chemotherapy. Among 42 patients with both peritoneal and extraperitoneal metastases, CSS was independently related to the completeness of cytoreduction score, location of extraperitoneal metastasis, and grade 3\u20134 complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mitomycin C\u2010IPC after CRS was associated with better survival outcomes than CRS alone in patients with resectable peritoneal metastasis of colorectal cancer. This study found that IPC had beneficial effects regarding P\u2010PFS in patients with both peritoneal and extraperitoneal metastases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27171","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T11:10:34Z","timestamp":1671016234000},"page":"668-677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Oncological impact of intraperitoneal chemotherapy after cytoreductive surgery for patients with colorectal peritoneal metastasis: A bi\u2010institutional retrospective analysis"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4821-2101","authenticated-orcid":false,"given":"Soo Yeun","family":"Park","sequence":"first","affiliation":[{"name":"Colorectal Cancer Center, Kyungpook National University Chilgok Hospital, School of Medicine Kyungpook National University Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Seok","family":"Park","sequence":"additional","affiliation":[{"name":"Colorectal Cancer Center, Kyungpook National University Chilgok Hospital, School of Medicine Kyungpook National University Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Colorectal Cancer Center, Kyungpook National University Chilgok Hospital, School of Medicine Kyungpook National University Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Gwang","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oncology\/Hematology, Kyungpook National University Chilgok Hospital, School of Medicine Kyungpook National University Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6012-1125","authenticated-orcid":false,"given":"Byung Woog","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Oncology\/Hematology, Kyungpook National University Chilgok Hospital, School of Medicine Kyungpook National University Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Ho","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Oncology\/Hematology, Kyungpook National University Chilgok Hospital, School of Medicine Kyungpook National University Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeong Rok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Chonnam National University Hwasun Hospital and Medical School Hwasun Republic of 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