{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:26:07Z","timestamp":1768519567270,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Localisation techniques for nonpalpable breast cancer lesions and sentinel lymph node biopsy (SLNB) are associated with several drawbacks. A complete magnetic technique using magnetic seeds and superparamagnetic iron oxide tracer could be an interesting alternative. This study describes a clear protocol and the results of a combined magnetic approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From August 2021 to February 2022 40 patients undergoing breast conserving surgery with SLNB were eligible for inclusion. Localisation was performed under ultrasound or stereotactic guidance, 1 week before surgery. Subsequently, 1\u2009ml of tracer was injected at least 4\u2009cm away from the tumour. Technetium\u201099m (<jats:sup>99m<\/jats:sup>Tc) was injected 1 day before surgery as control procedure. Outcomes were SLNB time, a number of nodes detected with magnetic tracer including comparison with <jats:sup>99m<\/jats:sup>Tc, a success rate of malignant lesion detection and pathological margin assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 40 procedures were performed on 39 patients. A median of one node was retrieved. Sentinel nodes were retrieved using MagTrace\u00ae with a 92.5% detection rate compared to <jats:sup>99m<\/jats:sup>Tc. Wide local excision under magnetic guidance was successful in 35 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This paper describes a combined magnetic approach for breast\u2010conserving surgery and SLNB. An adapted protocol is described and could be used for implementation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27197","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T13:45:23Z","timestamp":1672839923000},"page":"776-781","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["An adapted protocol for magnetic localisation of nonpalpable breast cancer lesions and sentinel lymph nodes using a magnetic seed and superparamagnetic iron oxide tracer"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1863-7857","authenticated-orcid":false,"given":"Merel A.","family":"Spiekerman van Weezelenburg","sequence":"first","affiliation":[{"name":"Department of Surgery Zuyderland Medical Centre  Sittard\u2010Geleen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5582-2445","authenticated-orcid":false,"given":"Elisabeth R. M.","family":"van Haaren","sequence":"additional","affiliation":[{"name":"Department of Surgery Zuyderland Medical Centre  Sittard\u2010Geleen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6639-1601","authenticated-orcid":false,"given":"Loeki","family":"Aldenhoven","sequence":"additional","affiliation":[{"name":"Department of Surgery Zuyderland Medical Centre  Sittard\u2010Geleen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline N. A.","family":"Frotscher","sequence":"additional","affiliation":[{"name":"Department of Radiology Zuyderland Medical Centre  Sittard\u2010Geleen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachelle","family":"K\u00f6rver\u2010Steeman","sequence":"additional","affiliation":[{"name":"Department of Radiology Zuyderland Medical Centre  Sittard\u2010Geleen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0607-1171","authenticated-orcid":false,"given":"James","family":"van Bastelaar","sequence":"additional","affiliation":[{"name":"Department of Surgery Zuyderland Medical Centre  Sittard\u2010Geleen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee H.","family":"Bouwman","sequence":"additional","affiliation":[{"name":"Department of Surgery Zuyderland Medical Centre  Sittard\u2010Geleen The Netherlands"},{"name":"Department of Clinical Engineering, Faculty of Science and Engineering Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne L. J.","family":"Vissers","sequence":"additional","affiliation":[{"name":"Department of Surgery Zuyderland Medical Centre  Sittard\u2010Geleen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Surgery Zuyderland Medical Centre  Sittard\u2010Geleen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199409000-00015"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2020.06.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4048\/jbc.2017.20.3.217"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10283"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13040693"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07577-4"},{"key":"e_1_2_8_8_1","unstructured":"ThompsonW Arg\u00e1ezC.Magnetic Localization System for Sentinel lymph node biopsy: A Review of the Diagnostic Accuracy Cost\u2010Effectiveness and Guidelines. 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