{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:49:46Z","timestamp":1761061786482,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Next\u2010generation sequencing (NGS) personalizes cancer treatments. In this study, we analyze outcomes based on NGS testing for colorectal cancer\u00a0(CRC) and high\u2010grade appendiceal adenocarcinoma (HGA) with peritoneal metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of genomic analyses and outcomes in patients with CRC or HGA with peritoneal metastases at a high\u2010volume center from 2012 to 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010two patients (57 CRC, 35 HGA) were identified. Overall survival was longer for CRC (52.8 vs. 30.5 months, <jats:italic>p<\/jats:italic>\u2009=\u20090.03), though rates of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS\/HIPEC) were similar. Multiple genes were more frequently mutated in CRC, including KRAS (51% vs. 29%, <jats:italic>p<\/jats:italic>\u2009=\u20090.04), TP53 (47% vs. 20%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), and APC (46% vs. 6%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). For CRC, multivariate regression showed an increased hazard ratio (HR) with increasing peritoneal cancer index\u00a0(1.06 [1.01\u20131.11], <jats:italic>p<\/jats:italic>\u2009=\u20090.02) and a decreased HR following CRS\/HIPEC (0.30 [0.11\u20130.80], <jats:italic>p<\/jats:italic>\u2009=\u20090.02). PIK3CA mutation associated with significantly increased HR (3.62 [1.06\u201312.41], <jats:italic>p<\/jats:italic>\u2009=\u20090.04), though only in non\u2010CRS\/HIPEC patients. Multivariate analysis in the HGA group showed a benefit following CRS\/HIPEC (0.18 [0.06\u20130.61], <jats:italic>p<\/jats:italic>\u2009=\u20090.01) and for mucinous disease (0.38 [0.15\u20130.96], <jats:italic>p<\/jats:italic>\u2009=\u20090.04), while there was an increased HR with TP53 mutation (6.89 [2.12\u201322.44], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CRC and HGA with peritoneal spread have distinct mutational profiles. PIK3CA and TP53 mutations are associated with survival for CRC or HGA with peritoneal metastases, respectively.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27203","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T07:51:14Z","timestamp":1673596274000},"page":"831-840","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mutational profiles and prognostic impact in colorectal and high\u2010grade appendiceal adenocarcinoma with peritoneal metastases"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4201-166X","authenticated-orcid":false,"given":"Ryan B.","family":"Morgan","sequence":"first","affiliation":[{"name":"Department of Surgery, Biological Sciences Division University of Chicago  Chicago Illinois 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of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ardaman","family":"Shergill","sequence":"additional","affiliation":[{"name":"Department of Medicine, Biological Sciences Division University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blase","family":"Polite","sequence":"additional","affiliation":[{"name":"Department of Medicine, Biological Sciences Division University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8541-586X","authenticated-orcid":false,"given":"Kiran K.","family":"Turaga","sequence":"additional","affiliation":[{"name":"Department of Surgery, Biological Sciences Division University of Chicago  Chicago Illinois USA"},{"name":"Department of Surgery, Division of Surgical Oncology Yale University  Hew Haven CT 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