{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:01:22Z","timestamp":1783951282490,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Tumor deposit (TD) is a poor prognostic factor in colorectal cancer (CRC) patients. This study aimed to determine whether TD carry the same risk of peritoneal recurrence as known high\u2010risk (HR) features in CRC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort\u2010study of stage I\u2212III CRC patients from 2010 to 2015 was conducted. TD group was defined by the presence of TD on histopathology whereas HR group was defined by the presence of obstruction, perforation, or T4\u2010stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 151 patients with CRC were identified, of which 50 had TD and 101 had a HR feature. The overall risk of peritoneal recurrence was higher in the TD group versus HR group (36.0% vs. 19.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.03). The risk of peritoneum as the site of first recurrence was also higher in the TD group (22.0% vs. 12.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.03). Overall cancer recurrence at any site was also higher in the TD group (56.0% vs. 34.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.01). Median time to first recurrence was 1.2 (0.7\u22121.9) years in the TD group compared to 1.4 (0.8\u22122.1) years in the HR group (<jats:italic>p<\/jats:italic>\u2009=\u20090.31).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In non\u2010metastatic CRC patients, TD might have a higher risk of tumor recurrence versus their HR\u00a0counterparts. Alternative strategies for surveillance and treatment should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27207","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T12:57:44Z","timestamp":1676465864000},"page":"975-982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Tumor deposits are associated with a higher risk of peritoneal disease in non\u2010metastatic colorectal cancer patients"],"prefix":"10.1002","volume":"127","author":[{"given":"Hamza","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Surgery Johns Hopkins University Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2923-9096","authenticated-orcid":false,"given":"Shannon N.","family":"Radomski","sequence":"additional","affiliation":[{"name":"Department of Surgery Johns Hopkins University Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amn","family":"Siddiqi","sequence":"additional","affiliation":[{"name":"Department of Surgery Johns Hopkins University Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Surgery Johns Hopkins University Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dane C.","family":"Paneitz","sequence":"additional","affiliation":[{"name":"Department of Surgery Johns Hopkins University Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2794-7179","authenticated-orcid":false,"given":"Fabian M.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Surgery Johns Hopkins University Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan B.","family":"Greer","sequence":"additional","affiliation":[{"name":"Department of Surgery Johns Hopkins University Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800239017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000515)88:10<2228::AID-CNCR5>3.0.CO;2-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2018.02.007"},{"key":"e_1_2_9_5_1","volume-title":"AJCC Cancer Staging Manual","author":"Mahul BA","year":"2017"},{"key":"e_1_2_9_6_1","first-page":"1","article-title":"Prognostic value of tumor deposits for long\u2010term oncologic outcomes in patients with stage III colorectal cancer: a systematic review and meta\u2010analysis","volume":"37","author":"Moon JY","year":"2021","journal-title":"Int J Colorectal Dis"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.9091"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.14289"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1152-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2022.01.017"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001002"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2473-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b13ca2"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.27475"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000059"},{"key":"e_1_2_9_16_1","first-page":"233","article-title":"Tumor deposit is a poor prognostic indicator in patients who underwent simultaneous resection for synchronous colorectal liver metastases","volume":"8","author":"Lin Q","year":"2015","journal-title":"Onco Targets Ther"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2012.03.029"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPAWOLX7ADZQ2K"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01960"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.05.063"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30239-0"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30322-3"},{"key":"e_1_2_9_23_1","unstructured":"NCT02974556. Proactive management of endoperitoneal spread in colonic cancer (PROMENADE). University of Roma La Sapienza.2016.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02974556."},{"key":"e_1_2_9_24_1","unstructured":"NCT02614534. Clinical trial to evaluate safety and efficacy of hyperthermic intra\u2010peritoneal chemotherapy (HIPEC) with mitomycin C used during surgery for treatment of locally advanced colorectal carcinoma (HIPECT4). 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