{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:12:50Z","timestamp":1782400370254,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T00:00:00Z","timestamp":1678492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Methods<\/jats:title><jats:p>The Melanoma Institute of Australia (MIA) and Memorial Sloan Kettering Cancer Center (MSKCC) nomograms were developed to help guide sentinel lymph node biopsy (SLNB) decisions. Although statistically validated, whether these prediction models provide clinical benefit at National Comprehensive Cancer Network guideline\u2010endorsed thresholds is unknown. We conducted a net benefit analysis to quantify the clinical utility of these nomograms at risk thresholds of 5%\u201310% compared to the alternative strategy of biopsying all patients. External validation data for MIA and MSKCC nomograms were extracted from respective published studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MIA nomogram provided added net benefit at a risk threshold of 9% but net harm at 5%\u20138% and 10%. The MSKCC nomogram provided added net benefit at risk thresholds of 5% and 9%\u201310% but net harm at 6%\u20138%. When present, the magnitude of net benefit was small (1\u20133 net avoidable biopsies per 100 patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Neither model consistently provided added net benefit compared to performing SLNB for all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Based on published data, use of the MIA or MSKCC nomograms as decision\u2010making tools for SLNB at risk thresholds of 5%\u201310% does not clearly provide clinical benefit to patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27231","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T12:54:34Z","timestamp":1678539274000},"page":"1167-1173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Are the MIA and MSKCC nomograms useful in selecting patients with melanoma for sentinel lymph node biopsy?"],"prefix":"10.1002","volume":"127","author":[{"given":"Sharif","family":"Hosein","sequence":"first","affiliation":[{"name":"Dermatology Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrison M.","family":"Drebin","sequence":"additional","affiliation":[{"name":"Gastric and Mixed Tumor Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas R.","family":"Kurtansky","sequence":"additional","affiliation":[{"name":"Dermatology Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Olofsson Bagge","sequence":"additional","affiliation":[{"name":"Department of Surgery Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Sahlgrenska Center for Cancer Research, Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Coit","sequence":"additional","affiliation":[{"name":"Gastric and Mixed Tumor Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0923-153X","authenticated-orcid":false,"given":"Edmund K.","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Gastric and Mixed Tumor Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Dermatology Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613210"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)00141-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197511000-00007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31824c4b0b"},{"key":"e_1_2_8_6_1","unstructured":"NCCN Clinical Practice Guidelines in Oncology\u2014Cutaneous Melanoma. 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