{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:27:02Z","timestamp":1740104822138,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Ovarian metastases (OM) are a common site for metastases in gastrointestinal tumours with peritoneal disease. This study aimed to evaluate perioperative complications between patients with and without OM following cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for appendiceal\/colorectal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Female patients undergoing CRS\u2009\u00b1\u2009HIPEC for appendiceal\/colorectal tumours at a single centre from 2009 to 2020 were analysed. Patients were grouped according to presence or absence of OM at the time of CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 318 patients, 72 (22.6%) had OM. Operation duration was longer for patients with OM (332 vs. 276\u2009min, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Patients with OM achieved higher rates of complete cytoreduction (93% vs. 79%, <jats:italic>p<\/jats:italic>\u2009=\u20090.006) despite a higher peritoneal carcinomatosis index (13\u00a0vs. 7, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001)\u00a0and were more likely to require a blood transfusion (32% vs. 19%, <jats:italic>p<\/jats:italic>\u2009=\u20090.024) and a stoma (24% vs.10%, <jats:italic>p<\/jats:italic>\u2009=\u20090.005). Increasing age and presence of abdominal symptoms were independent predictors of major and all\u2010cause morbidity, respectively. The presence of abdominal symptoms was independently associated with all\u2010cause morbidity in the OM group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results may assist with preoperative counselling. Prospective multicentre datasets are needed to evaluate morbidity in one\u2010 versus two\u2010stage approaches for those with abdominal symptoms and OM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27244","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T07:41:21Z","timestamp":1679384481000},"page":"66-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Perioperative outcomes of cytoreductive surgery for tumours of colorectal or appendiceal origin with ovarian involvement"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3079-1117","authenticated-orcid":false,"given":"Jessica F. R.","family":"Wagstaff","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology Peter MacCallum Cancer Centre Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3532-8343","authenticated-orcid":false,"given":"Michael P.","family":"Flood","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Peter MacCallum Cancer Centre Melbourne Victoria Australia"},{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Mohan","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Peter MacCallum Cancer Centre Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary D.","family":"McBain","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Peter MacCallum Cancer 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