{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T19:00:15Z","timestamp":1769972415552,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Malignant sex cord\u2010stromal cell tumours (SCST) account for only 7% of ovarian malignancies. The Arbeitsgemeinschaft fuer Gynaekologische Onkologie (AGO) study group has established a clinicopathological database to provide an overview of the current treatment strategies and survival of SCST patients and to identify research needs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty centres provided mixed retro\u2010 and prospective data of patients with tumour specimens and second\u2010opinion pathology review treated between 2000 and 2014. Descriptive analyses of treatment strategies, Kaplan\u2013Meier curves and cox regression analyses were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and sixty\u2010two SCST patients were included. One hundred and ninety\u2010one Granulosa\u2010cell tumour (GCT) and 17 Sertoli\u2010Leydig cell tumour (SLCT) patients were stage I disease (&gt;80%). Forty four GCT (18.7%) and two (8.3%) SLCT patients received adjuvant systemic treatment. After a median observation time of 78.2 months, 46% of all SCST patients experienced disease recurrence, treated predominantly with secondary debulking surgery (&gt; 90%). Advanced FIGO stage, lymph node involvement and intra\u2010operative capsule rupture were associated with disease recurrence on univariate analysis (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Median OS time was not reached.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In this analysis of SCST patients, adjuvant chemotherapy was unable to prevent disease recurrence. Despite high recurrence rates, overall survival rates were excellent.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27248","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T14:21:30Z","timestamp":1680013290000},"page":"111-118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Treatment and survival of patients with malignant ovarian sex cord\u2010stromal cell tumours: An analysis of the Arbeitsgemeinschaft f\u00fcr Gyn\u00e4kologische Onkologie (AGO) study group CORSETT database"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6355-2820","authenticated-orcid":false,"given":"Maximilian","family":"Klar","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Freiburg Faculty of Medicine University of Freiburg Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Plett","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Gynaecological Oncology Ev. Kliniken Essen\u2010Mitte Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Harter","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Gynaecological Oncology Ev. Kliniken Essen\u2010Mitte Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Heitz","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Gynaecological Oncology Ev. Kliniken Essen\u2010Mitte Essen Germany"},{"name":"Department of Gynecology with Center for Oncological Surgery Charite\u0301 University Medical Center Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Kommoss","sequence":"additional","affiliation":[{"name":"Department of Women's Health Tuebingen University Hospital Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas Daniel","family":"Hartkopf","sequence":"additional","affiliation":[{"name":"Department of Women's Health Tuebingen University Hospital Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Grube","sequence":"additional","affiliation":[{"name":"Department of Women's Health Tuebingen University Hospital Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Roser","sequence":"additional","affiliation":[{"name":"Department of Gynecology with Center for Oncological Surgery Charite\u0301 University Medical Center Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jalid","family":"Sehouli","sequence":"additional","affiliation":[{"name":"Department of Gynecology with Center for Oncological Surgery Charite\u0301 University Medical Center Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iona","family":"Braicu","sequence":"additional","affiliation":[{"name":"Department of Gynecology with Center for Oncological Surgery Charite\u0301 University Medical Center Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastian","family":"Czogalla","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital, LMU Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Burges","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital, LMU Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Bossart","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Freiburg Faculty of Medicine University of Freiburg Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mir Fuad","family":"Hasanov","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Universit\u00e4tsklinikum G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Link","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Universit\u00e4tsklinikum Carl Gustav Carus Dresden; 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