{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:54:30Z","timestamp":1763600070465,"version":"3.37.3"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fluid\u2013fluid levels (FFLs) is found in 10%\u201316% of giant cell tumor of bone (GCTB), and the presence of FFLs raises the suspicion of GCTB with secondary aneurysmal bone cyst (ABC), which can lead to increased intraoperative bleeding and, blurring the operative field, be associated with a risk of local recurrence. The first objective of this study is to determine whether secondary ABC is associated with a higher risk of local recurrence after curettage in patients with GCTB of the extremities. The second objective of this study is to investigate the sensitivity, specificity, positive predictive value, and negative predictive value of the presence of FFLs detected on magnetic resonance imaging (MRI) to diagnose secondary ABC associated with GCTB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and eighty patients with GCTB of the extremities who underwent curettage at the authors' institutions between 1980 and 2021 were included in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Secondary ABC was found in 36 of 280 patients (12.9%) and local recurrence occurred in 66 of 280 patients (23.6%). Multivariate analysis showed no significant correlation between secondary ABC and local recurrence (hazard ratio [HR]: 1.87 (95% confidence interval [CI]: 1.00\u20133.53]; <jats:italic>p<\/jats:italic>\u2009=\u20090.051). Preoperative MRI revealed FFLs in 13 of 82 patients (15.9%). Sensitivity, specificity, positive predictive value, and negative predictive value of FFLs detected on preoperative MRI to diagnose secondary ABC were 36.8%, 90.5%, 53.8%, and 82.6%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study showed that secondary ABC does not increase the risk of local recurrence after curettage in patients with GCTB of the extremities. Although rare, FFLs were present in patients with GCTB and half of those with FFLs detected on preoperative MRI had secondary ABC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27283","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T16:09:38Z","timestamp":1681402178000},"page":"350-358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Giant cell tumor of bone with secondary aneurysmal bone cyst does not have a higher risk of local recurrence"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8419-2008","authenticated-orcid":false,"given":"Shinji","family":"Tsukamoto","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Nara Medical University Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisaki","family":"Aiba","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Oncology IRCCS Istituto Ortopedico Rizzoli Bologna Italy"},{"name":"Department of Orthopedic Surgery Nagoya City University Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Righi","sequence":"additional","affiliation":[{"name":"Department of Pathology IRCCS Istituto Ortopedico Rizzoli Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Nitta","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Nara Medical University Kashihara\u2010city, Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Traversari","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Oncology IRCCS Istituto Ortopedico Rizzoli Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0807-0719","authenticated-orcid":false,"given":"Andreas F.","family":"Mavrogenis","sequence":"additional","affiliation":[{"name":"First Department of Orthopaedics, School of Medicine National and Kapodistrian University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanya","family":"Honoki","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Nara Medical University Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhito","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Nara Medical University Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide Maria","family":"Donati","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Oncology IRCCS Istituto Ortopedico Rizzoli Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costantino","family":"Errani","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Oncology IRCCS Istituto Ortopedico Rizzoli Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,13]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"440","volume-title":"WHO classification of tumours, 5th ed. 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