{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:44:21Z","timestamp":1790315061988,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Peritoneal mesothelioma (PM) is a rare malignancy originating from the peritoneal lining. Cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) is the standard\u2010of\u2010care for patients with isolated PM. Due to a paucity of prospective data there are several different HIPEC protocols. The aims of this study are to describe the CRS and HIPEC protocols for PM and patient outcomes across Canada.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter retrospective study was performed on patients diagnosed and treated for PM with CRS and HIPEC in four major peritoneal disease centers in Canada between 2000 and 2021. Data on patient characteristics, treatment patterns, postoperative morbidity, recurrence, and survival were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 72 patients were identified. Mean age was 52 years (17\u201375) and 37.5% were male. Epithelioid (70.1%) and multicystic (13%) mesothelioma were the most common subtypes. Twenty\u2010one patients (30%) were treated with neoadjuvant chemotherapy. CRS and HIPEC was performed in 64 patients (91.4%). Of these, the mean PCI was 22 (2\u201339) and cisplatin+doxorubicin was the most common HIPEC regimen (<jats:italic>n<\/jats:italic>\u2009=\u200933, 51.6%). A semi\u2010closed coliseum technique was used in 68.8% of HIPECs and the mean duration of surgery was 486\u2009min (90\u20131052). Clavien\u2010Dindo III or IV complications occurred in 12 patients (16.9%). With a median follow\u2010up of 24 months (0.2\u2013104.4), we found a 5\u2010year overall survival of 61% and a 5\u2010year recurrence\u2010free survival of 35%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CRS and HIPEC is a safe and effective treatment modality for well\u2010selected patients with PM, with some achieving prolonged survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27301","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T10:55:02Z","timestamp":1685444102000},"page":"595-603","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) for peritoneal mesothelioma: Canadian practices and outcomes"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1768-263X","authenticated-orcid":false,"given":"Melina","family":"Deban","sequence":"first","affiliation":[{"name":"Tom Baker Cancer Center Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadhim","family":"Taqi","sequence":"additional","affiliation":[{"name":"Vancouver General Hospital Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory C.","family":"Knapp","sequence":"additional","affiliation":[{"name":"QE II Health Sciences Center Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Soucisse","sequence":"additional","affiliation":[{"name":"H\u00f4pital Maisonneuve\u2010Rosemont Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Curry","sequence":"additional","affiliation":[{"name":"QE II 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