{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:02:54Z","timestamp":1761562974647,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In patients at high risk of peritoneal metastasis (PM) recurrence following surgical treatment of colon cancer (CC), second\u2010look laparoscopic exploration (SLLE) is mandatory; however, the best timing is unknown. We created a tool to refine the timing of early SLLE in patients at high risk of PM recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This international cohort study included patients who underwent CC surgery between 2009 and 2020. All patients had PM recurrence. Factors associated with PM\u2010free survival (PMFS) were assessed using Cox regression. The primary endpoint was early PM recurrence defined as a PMFS of &lt;6 months. A model (logistic regression) was fitted and corrected using bootstrap.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 235 patients were included. The median PMFS was 13 (IQR, 8\u201322) months, and 15.7% of the patients experienced an early PM recurrence. Synchronous limited PM and\/or ovarian metastasis (hazard ratio [HR]: 2.50; 95% confidence interval [CI]: [1.66\u20133.78]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were associated with a very high\u2010risk status requiring SLLE. T4 (HR: 1.47; 95% CI: [1.03\u20132.11]; <jats:italic>p<\/jats:italic>\u2009=\u20090.036), transverse tumor localization (HR: 0.35; 95% CI: [0.17\u20130.69]; <jats:italic>p<\/jats:italic>\u2009=\u20090.002), emergency surgery (HR: 2.06; 95% CI: [1.36\u20133.13]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), mucinous subtype (HR: 0.50; 95% CI [0.30, 0.82]; <jats:italic>p<\/jats:italic>\u2009=\u20090.006), microsatellite instability (HR: 2.29; 95% CI [1.06, 4.93]; <jats:italic>p<\/jats:italic>\u2009=\u20090.036), KRAS mutation (HR: 1.78; 95% CI: [1.24\u20132.55]; <jats:italic>p<\/jats:italic>\u2009=\u20090.002), and complete protocol of adjuvant chemotherapy (HR: 0.93; 95% CI: [0.89\u20130.96]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were also prognostic factors for PMFS. Thus, a model was fitted (area under the curve: 0.87; 95% CI: [0.82\u20130.92]) for prediction, and a cutoff of 150 points was identified to classify patients at high risk of early PM recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using a nomogram, eight prognostic factors were identified to select patients at high risk for early PM recurrence objectively. Patients reaching 150 points could benefit from an early SLLE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27359","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T10:54:00Z","timestamp":1685012040000},"page":"576-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A prediction model to refine the timing of an early second\u2010look laparoscopic exploration in patients with colon cancer at high risk of early peritoneal metastasis recurrence"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6799-7691","authenticated-orcid":false,"given":"Jade","family":"Fawaz","sequence":"first","affiliation":[{"name":"Department of Digestive Hepatobiliary and Liver Transplantation Surgery, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Assistance Publique\u2010H\u00f4pitaux de Paris and Sorbonne Universit\u00e9 Paris France"},{"name":"Sorbonne University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Pocard","sequence":"additional","affiliation":[{"name":"Department of Digestive Hepatobiliary and Liver Transplantation Surgery, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Assistance Publique\u2010H\u00f4pitaux de Paris and Sorbonne Universit\u00e9 Paris France"},{"name":"UMR INSERM 1275 CAP Paris\u2010Tech, Lariboisi\u00e8re Hospital Universit\u00e9 de Paris Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8051-1588","authenticated-orcid":false,"given":"Gabriel","family":"Liberale","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Institut Jules Bordet Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarisse","family":"Eveno","sequence":"additional","affiliation":[{"name":"Department of Digestive and Oncologic Surgery, Claude Huriez University Hospital Centre Hospitalier Universitaire (CHU) Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brice","family":"Malgras","sequence":"additional","affiliation":[{"name":"Department of Digestive and Endocrine Surgery B\u00e9gin Military Teaching Hospital  Saint\u2010Mand\u00e9 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Sideris","sequence":"additional","affiliation":[{"name":"Department of Surgery, Maisonneuve\u2010Rosemont Hospital University of Montreal  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"H\u00fcbner","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery Lausanne University Hospital CHUV Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Sabbagh","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery, 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