{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:02:47Z","timestamp":1783663367040,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Local control following stereotactic ablative radiotherapy (SABR) for patients with colorectal pulmonary metastases is reportedly lower than for metastases from other tumors. Such recurrences may still be amenable to salvage therapy. We describe our experience with salvage surgery in 17 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent salvage metastasectomy for a local recurrence following SABR for colorectal pulmonary metastases were identified from the surgical institutional databases of three Dutch major referral hospitals. Kaplan\u2013Meier survival analysis was performed to determine survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen patients underwent 20 salvage resections for local recurrence of colorectal pulmonary metastases. All patients had a progressive lesion on consecutive CT scans, with local uptake on <jats:sup>18<\/jats:sup>fluorodeoxyglucose\u2010positron emission tomography computed tomography (FDG\u2010PET CT), and were discussed in a thoracic oncology tumor board. Median time to local recurrence following SABR was 20 months (interquartile range [IQR]: 13\u221229). Fourteen procedures were performed minimally invasively. Extensive adhesions were observed during three procedures. A Clavien\u2013Dindo grade III\u2013IV complication occurred after four resections (20%). The 90\u2010day mortality was 0%. The estimated median overall survival and progression\u2010free survival following salvage resection were 71 months (confidence intervals [CI]: 50\u201392) and 39 months (CI: 19\u201358), respectively. Salvage resections were significantly more extensive, compared to the potential resection assessed on pre\u2010SABR imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our experience with 20 salvage pulmonary metastasectomy procedures for local recurrences following SABR in colorectal cancer patients demonstrates that salvage resection is a feasible option with acceptable morbidity and good oncological outcome in a highly selected cohort.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27404","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T13:01:22Z","timestamp":1689944482000},"page":"1114-1120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Salvage surgery for local recurrences after stereotactic ablative radiotherapy of colorectal pulmonary metastases"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3760-3027","authenticated-orcid":false,"given":"Martijn","family":"van Dorp","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery Amsterdam UMC location Vrije Universiteit Amsterdam Amsterdam the Netherlands"},{"name":"Cancer Center Amsterdam Imaging and Biomarkers Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semih","family":"\u00dcnal","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Amsterdam UMC location Vrije Universiteit Amsterdam Amsterdam the Netherlands"},{"name":"Cancer Center Amsterdam Imaging and Biomarkers Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Gooijer","sequence":"additional","affiliation":[{"name":"Department of Surgery Northwest Clinics Alkmaar the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Dickhoff","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Amsterdam UMC location Vrije Universiteit Amsterdam Amsterdam the Netherlands"},{"name":"Cancer Center Amsterdam Imaging and Biomarkers Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank Jozef Christiaan","family":"van den Broek","sequence":"additional","affiliation":[{"name":"Department of Surgery M\u00e1xima Medical Center Veldhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Kazemier","sequence":"additional","affiliation":[{"name":"Cancer Center Amsterdam Imaging and Biomarkers Amsterdam the Netherlands"},{"name":"Department of Surgery Amsterdam UMC Location Vrije Universiteit Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelmina 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