{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T01:46:12Z","timestamp":1774316772514,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hyperthermic intraoperative cisplatin (HIOC) is associated with acute kidney injury (AKI). Administration of high\u2010dose magnesium attenuates cisplatin\u2010induced AKI (CP\u2010AKI) in animal models but has not been rigorously examined in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We tested the feasibility and safety of different doses of magnesium in mesothelioma patients receiving HIOC. In Pilot Study 1, we administered a 36\u2010h continuous infusion of magnesium at 0.5\u2009g\/h, targeting serum magnesium levels between 3 and 4.8\u2009mg\/dL. In Pilot Study 2A, we administered a 6\u2009g bolus followed by an infusion starting at 2\u2009g\/h, titrated to achieve levels between 4 and 6\u2009mg\/dL. We eliminated the bolus in Pilot Study 2B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In Pilot Study 1, all five patients enrolled completed the study; however, median postoperative Mg levels were only 2.4\u2009mg\/dL. In Pilot Study 2A, two of four patients (50%) were withdrawn due to bradycardia during the bolus. In Pilot Study 2B, two patients completed the study whereas two developed postoperative bradycardia attributed to the magnesium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A 0.5\u2009g\/h infusion for 36\u2009h did not achieve therapeutic magnesium levels, while an infusion at 2\u2009g\/h\u00a0was associated with bradycardia. These studies informed the design of a randomized clinical trial testing whether intravenously Mg attenuates HIOC\u2010associated AKI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27412","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T11:58:40Z","timestamp":1694606320000},"page":"1141-1149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["High\u2010dose IV magnesium in mesothelioma patients receiving surgery with hyperthermic intraoperative cisplatin: Pilot studies and design of a phase II randomized clinical trial"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5747-2151","authenticated-orcid":false,"given":"Shruti","family":"Gupta","sequence":"first","affiliation":[{"name":"Division of Renal Medicine Brigham and Women's Hospital Boston Massachusetts USA"},{"name":"Adult Survivorship Program Dana\u2010Farber Cancer Institute Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia L.","family":"Wells","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arunima M.","family":"Jose","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Seitter","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea","family":"Feghali","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishant","family":"Devaraj","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip M.","family":"Hartigan","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology, Perioperative, and Pain Medicine Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Yacoubian","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology, Perioperative, and Pain Medicine Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Kwiatkowski","sequence":"additional","affiliation":[{"name":"Department of Medicine Brigham and Women's Hospital Boston USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna M.","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Thoracic Surgery Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julianne","family":"Barlow","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Thoracic Surgery Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3231-5491","authenticated-orcid":false,"given":"Raphael","family":"Bueno","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Thoracic Surgery Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Leaf","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08070715"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19991210)83:6<866::AID-IJC34>3.0.CO;2-9"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.7161"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-017-0392-z"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.12.037"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.02.046"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.05.033"},{"key":"e_1_2_10_9_1","first-page":"S1","article-title":"Kidney disease: improving global outcomes (KDIGO) acute kidney injury work group. 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