{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:03:19Z","timestamp":1791644599563,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Long\u2010term data evaluating clinical outcomes in patients with branch\u2010duct Intraductal papillary mucinous neoplasms (BD\u2010IPMN) without high\u2010risk stigmata (HRS) or worrisome features (WF) remain limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This observational cohort study included all patients diagnosed with BD\u2010IPMN without HRS or WF between 2003 and 2019 who were enrolled in a prospective surveillance program. Time\u2010to\u2010progression analysis was performed using a cumulative incidence function plot and survival analysis was conducted using Kaplan\u2013Meier.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up time for the 267 patient cohort was 44.5 months (interquartile range [IQR]: 24.1\u201372.2). Radiographic cyst growth was observed in 123 (46.1%) patients; 65 (24.3%) patients progressed to WF\/HRS. Twenty\u2010six (9.7%) patients were selected for resection during surveillance: 21 (80.8%) WF, 4 (15.4%) HRS; 1 (3.9%) transformed to mixed\u2010duct. Of all the patients who underwent resection, 5 (19.2%) had adenocarcinoma, and 1 (3.8%) had carcinoma\u2010in\u2010situ. The probability of any radiographic progression was 21.3% (5\u2010year) and 51.3% (10\u2010year). For the entire cohort, there was 1.1% mortality secondary to pancreatic adenocarcinoma and 8.2% all\u2010cause mortality. The 5\u2010year overall survival rate was 91.5%, and at 10 years, 81.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Approximately one in four patients with nonworrisome BD\u2010IPMN have progression to WF\/HRS stigmata during surveillance. However, the risk of malignant transformation remains low. Surveillance strategy remains prudent in this patient population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27414","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T12:59:54Z","timestamp":1690981194000},"page":"1087-1094","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Long\u2010term surveillance of branch\u2010duct intraductal papillary mucinous neoplasms without worrisome or high\u2010risk features"],"prefix":"10.1002","volume":"128","author":[{"given":"Courtney M.","family":"Lattimore","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery University of Virginia  Charlottesville Virginia USA"},{"name":"Surgical Outcomes Research Center, Department of Surgery University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William 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