{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:21:16Z","timestamp":1761974476862,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Prognostic scores are developed to facilitate the selection of patients with colorectal cancer peritoneal metastases (CRPM) for treatment with cytoreductive surgery (CRS)\u2009\u00b1\u2009intraperitoneal chemotherapy (IPC). Three prominent prognostic scores are the Peritoneal Surface Disease Severity Score (PSDSS), the Colorectal Peritoneal Metastases Prognostic Surgical Score (COMPASS), and the modified COloREctal\u2010Pc (mCOREP). We externally validate these scores and compare their predictive accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from consecutive CRPM patients who underwent CRS\/IPC from 1996 to 2018 was used to externally validate COMPASS, PSDSS, and mCOREP. Analysis evaluated the efficacy of each score in predicting (1) open\u2013close laparotomy\u2014those found at laparotomy to not be eligible for curative intent CRS\/IPC, (2) surgical futility\u2014those who underwent open\u2013close laparotomy, palliative debulking surgery, or had an overall survival of less than 12 months, and (3) overall and recurrence\u2010free survival (OS, RFS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prognostic scores were calculated for the 174\u2010patient external validation cohort. COMPASS was most accurate in predicting open\u2013close laparotomy, futile surgery, and survival (OS and RFS). Area under the curve (AUC) for open\u2013close prediction was 0.78 (95% confidence interval,\u00a0CI: 0.68\u20130.87), representing useful discrimination. However, AUC for futility prediction was 0.62 (95%\u00a0CI: 0.52\u20130.71), and C\u2010statistic for OS was 0.65 indicating only possibly helpful discrimination. C\u2010statistic for RFS was 0.59 indicating poor discrimination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While COMPASS showed the best statistical behavior, accuracy for several clinically relevant outcomes remains low, and thus applicability to clinical practice limited.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27416","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T12:15:54Z","timestamp":1692620154000},"page":"1150-1159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["External validation of prognostic scores and comparison of predictive accuracy for patients with colorectal cancer with peritoneal metastases considered for cytoreductive surgery and intraperitoneal chemotherapy"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6020-4588","authenticated-orcid":false,"given":"Mathew A.","family":"Kozman","sequence":"first","affiliation":[{"name":"Department of Surgery, Hepatobiliary and Surgical Oncology Unit St George Hospital Kogarah New South Wales Australia"},{"name":"Cancer Care Centre St George Hospital Kogarah New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver M.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hepatobiliary and Surgical Oncology Unit St George Hospital Kogarah New South Wales Australia"},{"name":"St George Hospital Clinical School University of New South Wales Sydney New South Wales Australia"},{"name":"School of Medicine University of Notre Dame Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winston","family":"Liauw","sequence":"additional","affiliation":[{"name":"Cancer Care Centre St George Hospital Kogarah New South Wales Australia"},{"name":"St George Hospital Clinical School University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9377-8521","authenticated-orcid":false,"given":"David L.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hepatobiliary and Surgical Oncology Unit St George Hospital Kogarah New South Wales Australia"},{"name":"St George Hospital Clinical School University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3474-9450","authenticated-orcid":false,"given":"Peter H.","family":"Cashin","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Section of Surgery, Uppsala University Akademiska Sjukhuset Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8679"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2013.10.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0487-4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.9285"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.10.012"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30599-4"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.187"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2018.1464668"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001593"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21169"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5211-6"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4516"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-6042-9"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318254f281"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3204-2"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002899"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"issue":"1","key":"e_1_2_10_20_1","first-page":"49","article-title":"Current methodologies for clinical assessment of patients with peritoneal carcinomatosis","volume":"15","author":"Jacquet PSP","year":"1996","journal-title":"J Exp Clin Cancer Res"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-012-0397-5"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199501000-00004"},{"key":"e_1_2_10_23_1","unstructured":"R Core Team.R: a language and environment for statistical computing. R Foundation for Statistical Computing; 2022. Accessed August 18 2023.https:\/\/www.R-project.org"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.12126"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20049"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-9-171"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21601"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-004-1577-y"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2005.09.016"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10527"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-008-9405-7"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-012-9881-7"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.27416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T10:31:38Z","timestamp":1700130698000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.27416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,21]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/jso.27416"],"URL":"https:\/\/doi.org\/10.1002\/jso.27416","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"type":"print","value":"0022-4790"},{"type":"electronic","value":"1096-9098"}],"subject":[],"published":{"date-parts":[[2023,8,21]]},"assertion":[{"value":"2023-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}