{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T19:07:13Z","timestamp":1769972833042,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The humerus is a common site of metastases and primary tumors. For some patients with a segmental defect and\/or diaphyseal cortical destruction a cemented intercalary device may provide a more reliable construct, however data on their use is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed 43 (28 male and 15 female) patients treated with an intercalary humeral spacer at a single tertiary referral center between 1989 and 2022. Humeral lesions were most commonly secondary to metastatic disease (<jats:italic>n<\/jats:italic>\u2009=\u200929, 68%), with 25 (58%) patients presenting with a pathologic fracture. Mean age and body mass index were 66 years and 27.9\u2009kg\/m<jats:sup>2<\/jats:sup>. First generation taper joint device were used in 22 patients and second\u2010generation lap device in 21 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following reconstruction the 2\u2010year overall survival was 30%. Mechanical complications occurred in 11 patients, most commonly aseptic loosening (<jats:italic>n<\/jats:italic>\u2009=\u20096, 14%). With death as a competing risk, the cumulative incidence of mechanical failure was 28% at 2\u2010years postoperative. Following the procedure, mean Musculoskeletal Tumor Society scores was 70% and mean shoulder elevation was 87\u00b0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reconstruction of the humeral diaphysis with an intercalary endoprosthesis provides restoration of function of the upper extremity, however, is associated with one in four patients having mechanical failure.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27458","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T09:16:14Z","timestamp":1695719774000},"page":"410-415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Durability of intercalary endoprosthesis for humeral reconstruction"],"prefix":"10.1002","volume":"129","author":[{"given":"Joshua R.","family":"Labott","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Heidenreich","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4192-4133","authenticated-orcid":false,"given":"Samuel E.","family":"Broida","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin L.","family":"Mills","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter S.","family":"Rose","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0390-1018","authenticated-orcid":false,"given":"Matthew T.","family":"Houdek","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200307000-00008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000093052.96273.a7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-20-00819"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20100924-29"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.93B8.26194"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2020.02.124"},{"issue":"363","key":"e_1_2_7_8_1","first-page":"240","article-title":"Biomechanical analysis of prophylactic fixation for middle third humeral impending pathologic fractures","author":"Damron TA","year":"1999","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200203000-00034"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-021-02250-1"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199606000-00012"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0748-7983(96)92450-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198206000-00034"},{"issue":"342","key":"e_1_2_7_14_1","first-page":"147","article-title":"Treatment of humeral shaft fractures by retrograde locked nailing","author":"Lin J","year":"1997","journal-title":"Clin Orthop Relat Res"},{"issue":"248","key":"e_1_2_7_15_1","first-page":"231","article-title":"Metastatic diaphyseal fractures of the shaft of the humerus. 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