{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:35:26Z","timestamp":1767987326465,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Primary liver sarcomas are rare malignancies. Prognostic factors associated with long\u2010term survival remain poorly understood. The objective of this study is to determine factors associated with long\u2010term survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Surveillance, Epidemiology, and End Results (SEER) database was queried to identify patients with visceral sarcoma arising from the liver. Demographic factors, tumor characteristics, resection status, and survival were evaluated. Multivariate Cox regression analysis was performed to determine predictors of survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 743 patients with primary hepatic sarcoma were identified. The median tumor size was 10\u2009cm. Only 30% (<jats:italic>n<\/jats:italic>\u2009=\u2009221) of patients in the cohort underwent surgery. The 5\u2010year overall survival rates were 47.9% for localized disease, 29.5% for regional disease, and 16.5% for distant disease, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001. Among patients who underwent surgical resection, patients with embryonal sarcoma had better 5\u2010year survival compared with angiosarcoma and other histologic subtypes. On multivariate analysis, surgery was associated with improved survival, while older age, higher stage, and angiosarcoma histology were the strongest independent predictors of poor survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Surgery remains the mainstay of treatment for this rare malignancy but is performed in less than one\u2010third of patients. Angiosarcoma histology is associated with worse overall survival, while surgical resection remains the strongest predictor of improved overall survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27477","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T13:15:12Z","timestamp":1696511712000},"page":"358-364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Primary sarcoma of the liver: A nationwide analysis of a rare mesenchymal tumor"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2366-3726","authenticated-orcid":false,"given":"Nicole","family":"Finney","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology University of California Irvine Orange California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tu","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology University of California Irvine Orange California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bima J.","family":"Hasjim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology University of California Irvine Orange California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Jakowatz","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology University of California Irvine Orange California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Chiao","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology University of California Irvine Orange California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0226-5005","authenticated-orcid":false,"given":"Oliver","family":"Eng","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology University of California Irvine Orange California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology University of California Irvine Orange California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeljika","family":"Jutric","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology University of California Irvine Orange California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology University of California Irvine Orange California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuy B.","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology University of California Irvine Orange California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"277","article-title":"Liver cancer study group of Japan","volume":"211","author":"Primary liver cancer in Japan. 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