{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T21:11:14Z","timestamp":1772399474820,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Current NCCN guidelines discourage repeat sentinel lymph node (SLN) surgery in patients with local recurrence (LR) of breast cancer following prior mastectomy. This study addresses the feasibility and therapeutic impact of this approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified 73 patients managed with repeat SLN surgery for post\u2212mastectomy isolated LR. Lymphatic mapping was performed using radioisotope with or without lymphoscintigraphy and\/or blue dye. Successful SLN surgery was defined as retrieval of \u22651 SLN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SLN surgery was successful in 65\/73 (89%), identifying a median of 2 (range 1\u20134) SLNs, with 10\/65 (15%) SLN\u2010positive. Among these, 5\/10 (50%) proceeded to ALND. In unsuccessful cases, 1\/8 (13%) proceeded to ALND. Seven of 10 SLN\u2010positive patients and 50\/55 SLN\u2010negative patients received adjuvant radiotherapy. Chemotherapy was administered in 31 (42%) and endocrine therapy in 50 of 57 HR+ patients (88%). After 28 months median follow\u2010up, eight patients relapsed with the first site local in two, distant in five, and synchronous local\/distant in one. No nodal recurrences were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SLN surgery for patients with LR post\u2212mastectomy is feasible and informative. This approach appears oncologically sound, decreases axillary dissection rates and may be used to tailor adjuvant radiation target volumes and systemic therapies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27496","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T11:33:42Z","timestamp":1699270422000},"page":"461-467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Repeat sentinel lymph node surgery for locally recurrent breast cancer after prior mastectomy"],"prefix":"10.1002","volume":"129","author":[{"given":"Amy K.","family":"Schulze","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Breast and Melanoma Surgical Oncology Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya L.","family":"Hoskin","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic 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