{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T17:10:44Z","timestamp":1776705044294,"version":"3.51.2"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>This multicenter retrospective series of consecutive extra\u2010spinal aneurysmal bone cysts aims to identify risk factors for treatment failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Aneurysmal bone cysts treated within seven collaborating centers with over 12\u2010months follow\u2010up were eligible for inclusion. Survival analyses were performed to identify variables associated with recurrence using log\u2010rank tests and Cox proportional hazard regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and fifteen (M:F 60:55) patients were included. Median age at presentation was 13 years and median follow\u2010up was 27 months. Seventy\u2010five\u00a0patients underwent surgical curettage and 27% of these required further intervention for recurrence. Of the 30 patients who underwent biopsy with limited percutaneous curettage as initial procedure, 47% required no further treatment. Patients under 13 years (log\u2010rank <jats:italic>p<\/jats:italic>\u2009=\u20090.006, HR 2.3,\u00a0<jats:italic>p<\/jats:italic>\u2009=\u20090.011) and those treated who had limited curettage (log\u2010rank <jats:italic>p<\/jats:italic>\u2009=\u20090.001, HR 2.7,\u00a0<jats:italic>p<\/jats:italic>\u2009=\u20090.002) had a higher risk of recurrence\/persistence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a high risk of recurrence following surgical treatment for aneurysmal bone cysts\u00a0and this risk is higher in young patients. However, the cyst heals in a substantial number of patients who have a limited curettage at the time of biopsy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27499","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T21:13:20Z","timestamp":1700082800000},"page":"601-608","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Aneurysmal bone cysts: A UK wide tumor center experience"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3370-8174","authenticated-orcid":false,"given":"Luckshman","family":"Bavan","sequence":"first","affiliation":[{"name":"Oxford University Hospitals NHS Foundation Trust Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Eastley","sequence":"additional","affiliation":[{"name":"Royal Orthopaedic Hospital NHS Foundation Trust Birmingham 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