{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:01:56Z","timestamp":1791316916110,"version":"4.3.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\u00a0and Objectives<\/jats:title><jats:p>Many heterogenous orthotopic liver transplant (OLT) protocols exist for patients with unresectable cholangiocarcinoma. Little is known about the incidence, predictors for, and the significance of achieving a pathologic complete response (pCR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a systematic review through September 2022 of the PubMed, Embase, and Web of Science databases. A random\u2010effect meta\u2010analysis was conducted to pool data across studies with reported pCR rates. Heterogeneity between treatment protocols was assessed via subgroup analysis. The pCR and 1\u2010, 3\u2010, and 5\u2010year recurrence\u2010free survival (RFS) and overall survival (OS) rates were extracted as outcomes of interest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 15 studies reported pCR rates and were grouped by use of the Mayo protocol (4\/15), stereotactic body radiation therapy\u00a0(2\/15), and an Other category (9\/15). The pooled pCR rate among all studies was 32%. Both radiation technique and duration of CHT showed no significant association with pCR (<jats:italic>p<\/jats:italic>\u2009=\u20090.05 and 0.13, respectively). Pooled 1\u2010year RFS and OS after any neoadjuvant therapy and OLT was 80% (95% confidence interval [CI], 0.61\u20130.91), and 91% (95% CI, 0.87\u20130.94), respectively. There was no 1\u2010year OS difference detected among the three groups. pCR was not associated with OS in the meta\u2010regression. Pooled 3\u2010 and 5\u2010year OS among all studies was 72% and 61%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The pooled incidence of pCR was 32%. Differences in radiation technique did not appear to influence pCR rates and upon meta\u2010regression, pCR was not a surrogate marker for survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27511","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T03:45:12Z","timestamp":1700624712000},"page":"574-583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A systematic review and meta\u2010analysis of pathologic complete response rates for patients with cholangiocarcinoma treated on liver transplant protocols"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9475-2072","authenticated-orcid":false,"given":"Trudy C.","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clayton P.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua S.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine Statistics Core University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Burton","sequence":"additional","affiliation":[{"name":"Louise M. Darling Biomedical Library University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Medicine Statistics Core University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randa","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Utah Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan B.","family":"Ludmir","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann C.","family":"Raldow","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of California Los Angeles 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