{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:18:10Z","timestamp":1789510690182,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Squamous cell carcinoma of the bladder (SCCB) is a rare disease composing 2%\u22125% of all bladder cancers with no consensus regarding treatment. The present study aims to analyze the outcomes of established treatments, namely chemotherapy, radiation, and surgery, to guide clinical decision\u2010making for patients with non\u2010schistosomal SCCB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with bladder SCC diagnosed between 2000 and 2018 were reviewed utilizing data from the Surveillance, Epidemiology, and End Results Registry (SEER) program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 5653 patients with SCCB were identified; median survival was 13 months and was significantly decreased in patients treated with chemotherapy or radiation (median survival of 9 or 12 months, respectively). Patients treated with both surgery and radiotherapy saw a decreased 5 year overall survival (OS) of 14%, compared to 35% for those treated with surgery alone (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Furthermore, patients treated with surgery, chemotherapy, and radiotherapy saw a decreased 5 year OS of 20%, compared with 25% for those that received surgery and chemotherapy only (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Finally, surgical intervention provided an increased 5 year OS for patients with locoregional disease only; those with distant disease saw no increase in 5 year OS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on this study's analysis, radical surgery may be the most effective treatment for this disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.27525","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T08:42:15Z","timestamp":1700556135000},"page":"649-658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Squamous cell carcinoma of the bladder: Demographics and outcomes associated with surgery and radiotherapy"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2322-8345","authenticated-orcid":false,"given":"Michael C.","family":"Larkins","sequence":"first","affiliation":[{"name":"Brody School of Medicine East Carolina University Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melisa","family":"Pasli","sequence":"additional","affiliation":[{"name":"Brody School of Medicine East Carolina University Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Brody School of Medicine East Carolina University Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidan","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Brody School of Medicine East Carolina University Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"SEER [Internet]. Cancer of the urinary bladder\u2014cancer stat facts. 2023.https:\/\/seer.cancer.gov\/statfacts\/html\/urinb.html"},{"key":"e_1_2_10_3_1","unstructured":"NCCN clinical practice guidelines in oncology (NCCN guidelines\u00ae)\u2014bladder cancer [Internet]. 2023.https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/bladder.pdf"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0259272"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.01.008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22853"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aju.2016.07.001"},{"key":"e_1_2_10_8_1","unstructured":"SEER [Internet]. Collaborative stage. 2023.https:\/\/seer.cancer.gov\/tools\/collabstaging\/index.html"},{"key":"e_1_2_10_9_1","first-page":"648","volume-title":"AJCC Cancer Staging Manual","author":"Edge SB","year":"2010"},{"key":"e_1_2_10_10_1","unstructured":"Cancer staging\u2014NCI [Internet]. 2015. Accessed August 18 2023.https:\/\/www.cancer.gov\/about-cancer\/diagnosis-staging\/staging"},{"key":"e_1_2_10_11_1","first-page":"1","article-title":"Carcinome \u00e9pidermo\u00efde de la vessie: exp\u00e9rience r\u00e9trospective dans un h\u00f4pital universitaire marocain et revue de la litt\u00e9rature","volume":"37","author":"Kadouri Y","year":"2020","journal-title":"Pan Afr Med J [Internet]"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2021.08.049"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-023-04978-7"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.690324"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-022-01166-6"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/08941939.2020.1812776"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-35761-w"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.707418"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31805c9cd9"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.27525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T03:46:21Z","timestamp":1707277581000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.27525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,20]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/jso.27525"],"URL":"https:\/\/doi.org\/10.1002\/jso.27525","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,20]]},"assertion":[{"value":"2023-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}